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ICD-10 Guide
ICD-10 CodesChapter 3: Diseases of the blood and blood-forming organsD51

D51

Billable

Vitamin B12 deficiency anemia

Chapter 3:Diseases of the blood and blood-forming organs

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/05/2025

Code Description

ICD-10 D51 is a billable code used to indicate a diagnosis of vitamin b12 deficiency anemia.

Key Diagnostic Point:

Vitamin B12 deficiency anemia is a type of macrocytic anemia characterized by a deficiency of vitamin B12, which is essential for red blood cell formation and neurological function. This condition can arise from inadequate dietary intake, malabsorption syndromes, or intrinsic factor deficiency, leading to impaired DNA synthesis in red blood cells. Clinically, patients may present with symptoms such as fatigue, pallor, shortness of breath, and neurological manifestations like paresthesia or cognitive disturbances. Diagnosis typically involves blood tests showing macrocytic anemia, low serum vitamin B12 levels, and elevated methylmalonic acid and homocysteine levels. Treatment primarily involves vitamin B12 supplementation, either orally or via intramuscular injections, depending on the severity and underlying cause of the deficiency. Regular monitoring of hemoglobin levels and vitamin B12 status is essential to assess treatment efficacy and prevent complications.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Differentiating between types of anemia (e.g., iron deficiency vs. B12 deficiency)
  • Identifying underlying causes of B12 deficiency (e.g., pernicious anemia, dietary insufficiency)
  • Understanding the relationship between B12 and neurological symptoms
  • Managing co-existing conditions that may complicate diagnosis and treatment

Audit Risk Factors

  • Inadequate documentation of symptoms and diagnostic tests
  • Failure to specify the underlying cause of B12 deficiency
  • Incorrect coding of co-existing conditions
  • Lack of follow-up documentation to support ongoing treatment

Specialty Focus

Medical Specialties

Hematology

Documentation Requirements

Detailed lab results, patient history, and treatment plans must be documented.

Common Clinical Scenarios

Patients presenting with fatigue, pallor, and neurological symptoms.

Billing Considerations

Ensure that all laboratory values are clearly documented to support the diagnosis.

Primary Care

Documentation Requirements

Comprehensive patient history, dietary assessments, and follow-up care notes.

Common Clinical Scenarios

Routine screening for anemia in at-risk populations, such as the elderly or vegetarians.

Billing Considerations

Document any dietary restrictions or malabsorption issues that may contribute to B12 deficiency.

Coding Guidelines

Inclusion Criteria

Use D51 When
  • According to ICD
  • 10 guidelines, D51 should be used when there is clear documentation of vitamin B12 deficiency anemia
  • It is important to specify the underlying cause when applicable, such as pernicious anemia or dietary insufficiency

Exclusion Criteria

Do NOT use D51 When
  • Exclusion criteria include anemia due to other deficiencies or conditions

Related CPT Codes

85025CPT Code

Complete blood count (CBC)

Clinical Scenario

Used to evaluate anemia and monitor treatment response.

Documentation Requirements

Document the reason for the CBC and any relevant findings.

Specialty Considerations

Hematologists may require additional tests to assess underlying causes.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of vitamin B12 deficiency anemia, enabling better tracking of prevalence and treatment outcomes. This specificity aids in research and improves patient care.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of vitamin B12 deficiency anemia, enabling better tracking of prevalence and treatment outcomes. This specificity aids in research and improves patient care.

Reimbursement & Billing Impact

The transition to ICD-10 has allowed for more specific coding of vitamin B12 deficiency anemia, enabling better tracking of prevalence and treatment outcomes. This specificity aids in research and improves patient care.

Resources

Clinical References

  • •
    CDC Vitamin B12 Deficiency

Coding & Billing References

  • •
    CDC Vitamin B12 Deficiency

Frequently Asked Questions

What are the common causes of vitamin B12 deficiency anemia?

Common causes include dietary insufficiency, malabsorption syndromes (such as pernicious anemia or gastrointestinal surgeries), and certain medications that affect B12 absorption.