Delta-beta thalassemia
ICD-10 D56.2 is a billable code used to indicate a diagnosis of delta-beta thalassemia.
Delta-beta thalassemia is a rare form of thalassemia characterized by a combined deficiency of both delta and beta globin chains in hemoglobin. This condition results from mutations in the HBB gene, which encodes the beta-globin subunit of hemoglobin. Patients with delta-beta thalassemia typically present with varying degrees of anemia, which can be classified as microcytic and hypochromic due to the ineffective erythropoiesis and hemolysis associated with the disorder. Clinical manifestations may include fatigue, pallor, splenomegaly, and jaundice. The severity of symptoms often correlates with the specific genetic mutations present and the degree of globin chain imbalance. Diagnosis is confirmed through hemoglobin electrophoresis, which reveals abnormal hemoglobin patterns. Management may involve regular blood transfusions, iron chelation therapy, and in some cases, hematopoietic stem cell transplantation. Genetic counseling is also recommended for affected families due to the hereditary nature of the condition.
Detailed lab results, including hemoglobin electrophoresis and genetic testing.
Management of patients with chronic anemia requiring transfusions.
Documentation must clearly indicate the type of thalassemia and any associated complications.
Family history and genetic counseling notes.
Assessment of at-risk family members and prenatal testing.
Genetic test results must be included to support diagnosis.
Used for monitoring anemia in patients with delta-beta thalassemia.
Document the reason for the CBC and any relevant clinical findings.
Hematologists should ensure that the CBC results are linked to the diagnosis.
Delta-beta thalassemia is a genetic blood disorder characterized by a deficiency in both delta and beta globin chains, leading to anemia and other related complications.
