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ICD-10 Guide
ICD-10 CodesD57.1

D57.1

Billable

Sickle-cell disease without crisis

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/05/2025

Code Description

ICD-10 D57.1 is a billable code used to indicate a diagnosis of sickle-cell disease without crisis.

Key Diagnostic Point:

Sickle-cell disease (SCD) is a genetic blood disorder characterized by the presence of abnormal hemoglobin, known as hemoglobin S (HbS), which causes red blood cells to assume a rigid, sickle shape. This abnormality leads to hemolytic anemia, where the lifespan of red blood cells is significantly reduced, resulting in chronic anemia. Patients with SCD often experience episodes of pain known as sickle cell crises due to vaso-occlusive events, but the code D57.1 specifically refers to the condition when the patient is not experiencing such a crisis. The disease is inherited in an autosomal recessive pattern, meaning that both parents must carry the sickle cell trait for a child to be affected. SCD can lead to various complications, including increased risk of infections, acute chest syndrome, and organ damage due to chronic hemolysis and vaso-occlusion. Management typically involves regular monitoring, pain management, and preventive measures such as vaccinations and hydroxyurea therapy to reduce the frequency of crises and improve overall health outcomes.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Differentiating between sickle cell disease and sickle cell trait
  • Understanding the various complications associated with SCD
  • Proper documentation of the absence of crisis
  • Knowledge of related hemolytic anemias and their coding

Audit Risk Factors

  • Inadequate documentation of the patient's clinical status
  • Failure to specify the absence of crisis
  • Misclassification of sickle cell trait versus disease
  • Lack of supporting lab results for hemolytic anemia

Specialty Focus

Medical Specialties

Hematology

Documentation Requirements

Detailed patient history, lab results showing hemoglobin levels, and evidence of chronic management.

Common Clinical Scenarios

Routine follow-up visits for anemia management, monitoring for complications, and treatment adjustments.

Billing Considerations

Ensure documentation reflects the absence of crisis and any ongoing treatment plans.

Genetics

Documentation Requirements

Genetic testing results, family history of sickle cell disease, and counseling notes.

Common Clinical Scenarios

Genetic counseling sessions for families with a history of sickle cell disease.

Billing Considerations

Accurate coding of genetic counseling sessions and the implications for family planning.

Coding Guidelines

Inclusion Criteria

Use D57.1 When
  • According to ICD
  • 10 guidelines, D57
  • 1 should be used when the patient has a confirmed diagnosis of sickle
  • cell disease without any acute crisis
  • It is important to document the patient's clinical status and any ongoing treatment

Exclusion Criteria

Do NOT use D57.1 When
No specific exclusions found.

Related ICD-10 Codes

Related CPT Codes

36415CPT Code

Collection of venous blood by venipuncture

Clinical Scenario

Used for routine blood tests to monitor hemoglobin levels in patients with sickle-cell disease.

Documentation Requirements

Document the reason for blood draw and any relevant clinical history.

Specialty Considerations

Hematology specialists should ensure that lab results are clearly linked to the diagnosis.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of sickle-cell disease, improving the ability to capture the nuances of the condition, including the differentiation between stable disease and acute crises.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of sickle-cell disease, improving the ability to capture the nuances of the condition, including the differentiation between stable disease and acute crises.

Reimbursement & Billing Impact

The transition to ICD-10 has allowed for more specific coding of sickle-cell disease, improving the ability to capture the nuances of the condition, including the differentiation between stable disease and acute crises.

Resources

Clinical References

  • •
    Sickle Cell Disease Association of America

Coding & Billing References

  • •
    Sickle Cell Disease Association of America

Frequently Asked Questions

What is the difference between sickle cell disease and sickle cell trait?

Sickle cell disease is a genetic disorder characterized by the presence of two copies of the sickle cell gene, leading to significant health issues. Sickle cell trait occurs when an individual has one copy of the sickle cell gene and one normal gene, typically resulting in no symptoms but the ability to pass the gene to offspring.