Sickle-cell trait
ICD-10 D57.3 is a billable code used to indicate a diagnosis of sickle-cell trait.
Sickle-cell trait (SCT) is a genetic condition characterized by the presence of one sickle hemoglobin gene (HbS) and one normal hemoglobin gene (HbA). Individuals with SCT typically do not exhibit the severe symptoms associated with sickle cell disease (SCD), as they produce enough normal hemoglobin to prevent significant hemolysis or vaso-occlusive crises. However, they may experience mild anemia under extreme conditions such as high altitude, dehydration, or intense physical exertion. SCT is inherited in an autosomal recessive pattern, meaning that a child must inherit the sickle gene from both parents to develop SCD. The trait is more prevalent in individuals of African, Mediterranean, Middle Eastern, and Indian descent, reflecting the evolutionary advantage it provides against malaria. Diagnosis is usually made through hemoglobin electrophoresis or genetic testing. While SCT is generally asymptomatic, it is crucial for affected individuals to be aware of their status, especially when considering family planning or engaging in activities that may pose health risks.
Documentation of hemoglobin electrophoresis results and family history of sickle cell disease.
Patients presenting for routine screening or preoperative evaluations.
Ensure that the distinction between sickle cell trait and sickle cell disease is clearly documented.
Genetic counseling notes and family pedigree charts.
Patients seeking genetic testing or counseling regarding family planning.
Document the implications of SCT for offspring and potential health risks.
Used to confirm the diagnosis of sickle-cell trait.
Results of the hemoglobin electrophoresis must be documented.
Hematology specialists should ensure that the test results are clearly linked to the diagnosis.
Sickle-cell trait occurs when an individual inherits one sickle hemoglobin gene and one normal hemoglobin gene, typically resulting in no significant symptoms. Sickle-cell disease occurs when an individual inherits two sickle hemoglobin genes, leading to severe health complications.
