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ICD-10 Guide
ICD-10 CodesD57.413

D57.413

Billable

Sickle-cell thalassemia, unspecified, with cerebral vascular involvement

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/05/2025

Code Description

ICD-10 D57.413 is a billable code used to indicate a diagnosis of sickle-cell thalassemia, unspecified, with cerebral vascular involvement.

Key Diagnostic Point:

Sickle-cell thalassemia is a complex hemolytic anemia resulting from the combination of sickle cell disease and thalassemia, leading to a range of clinical manifestations. This specific code indicates that the patient has an unspecified type of sickle-cell thalassemia and is experiencing cerebral vascular involvement, which may manifest as strokes or transient ischemic attacks due to the sickling of red blood cells obstructing cerebral blood flow. The condition is characterized by chronic hemolysis, anemia, and potential complications such as vaso-occlusive crises, infections, and organ damage. Genetic factors play a significant role, as both sickle cell disease and thalassemia are inherited disorders. The management of patients with this condition often requires a multidisciplinary approach, including hematology, neurology, and primary care, to address the various complications and ensure comprehensive care.

Code Complexity Analysis

Complexity Rating: High

High Complexity

Complexity Factors

  • Combination of two genetic disorders (sickle cell disease and thalassemia)
  • Variability in clinical presentation and severity
  • Need for precise documentation of cerebral vascular involvement
  • Potential for multiple co-morbid conditions

Audit Risk Factors

  • Inadequate documentation of cerebral vascular events
  • Misclassification of the type of thalassemia
  • Failure to document the severity of anemia
  • Lack of clarity on the patient's genetic background

Specialty Focus

Medical Specialties

Hematology

Documentation Requirements

Detailed history of hemolytic anemia, genetic testing results, and treatment plans.

Common Clinical Scenarios

Management of vaso-occlusive crises, blood transfusions, and hydroxyurea therapy.

Billing Considerations

Ensure accurate documentation of laboratory results and response to treatments.

Neurology

Documentation Requirements

Neurological assessments, imaging studies, and documentation of any cerebrovascular events.

Common Clinical Scenarios

Evaluation of stroke symptoms, management of neurological deficits, and follow-up care.

Billing Considerations

Document the relationship between sickle-cell thalassemia and neurological complications.

Coding Guidelines

Inclusion Criteria

Use D57.413 When
  • Follow ICD
  • CM guidelines for coding hemolytic anemias and ensure that all relevant clinical details are documented
  • Include any associated conditions and specify the type of cerebral vascular involvement

Exclusion Criteria

Do NOT use D57.413 When
No specific exclusions found.

Related ICD-10 Codes

Related CPT Codes

36415CPT Code

Collection of venous blood by venipuncture

Clinical Scenario

Used for obtaining blood samples for hemoglobin electrophoresis.

Documentation Requirements

Document the reason for blood draw and any relevant clinical history.

Specialty Considerations

Ensure that the specialty performing the procedure is noted.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of complex conditions like sickle-cell thalassemia, improving the accuracy of patient records and facilitating better management of care.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of complex conditions like sickle-cell thalassemia, improving the accuracy of patient records and facilitating better management of care.

Reimbursement & Billing Impact

The transition to ICD-10 has allowed for more specific coding of complex conditions like sickle-cell thalassemia, improving the accuracy of patient records and facilitating better management of care.

Resources

Clinical References

  • •
    CDC Sickle Cell Disease Resources

Coding & Billing References

  • •
    CDC Sickle Cell Disease Resources

Frequently Asked Questions

What is the significance of cerebral vascular involvement in sickle-cell thalassemia?

Cerebral vascular involvement indicates that the sickle-shaped cells are obstructing blood flow to the brain, which can lead to serious complications such as stroke. It is crucial for management and treatment planning.