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ICD-10 Guide
ICD-10 CodesD59.12

D59.12

Billable

Cold autoimmune hemolytic anemia

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/05/2025

Code Description

ICD-10 D59.12 is a billable code used to indicate a diagnosis of cold autoimmune hemolytic anemia.

Key Diagnostic Point:

Cold autoimmune hemolytic anemia (CAHA) is a type of hemolytic anemia characterized by the premature destruction of red blood cells due to the presence of autoantibodies that react at lower temperatures. This condition often occurs in association with certain infections, lymphoproliferative disorders, or can be idiopathic. Patients may present with symptoms such as fatigue, pallor, jaundice, and splenomegaly. The hemolysis is typically triggered by exposure to cold temperatures, leading to agglutination of red blood cells and subsequent hemolysis upon rewarming. Laboratory findings often include a positive direct Coombs test, elevated lactate dehydrogenase (LDH), decreased haptoglobin, and reticulocytosis. Management may involve avoiding cold exposure, corticosteroids, and in severe cases, splenectomy or immunosuppressive therapy. Understanding the underlying causes and associated conditions is crucial for effective treatment and management.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Differentiation from other types of hemolytic anemia
  • Need for comprehensive patient history to identify triggers
  • Potential overlap with other autoimmune disorders
  • Variability in clinical presentation and laboratory findings

Audit Risk Factors

  • Inadequate documentation of autoimmune nature
  • Failure to note associated conditions or infections
  • Misclassification with other hemolytic anemias
  • Lack of detailed clinical history

Specialty Focus

Medical Specialties

Hematology

Documentation Requirements

Detailed lab results, patient history, and treatment plans.

Common Clinical Scenarios

Diagnosis and management of hemolytic anemias, monitoring of treatment response.

Billing Considerations

Ensure clear documentation of autoimmune tests and any associated conditions.

Rheumatology

Documentation Requirements

Comprehensive autoimmune panel results and patient symptomatology.

Common Clinical Scenarios

Management of autoimmune disorders that may lead to hemolytic anemia.

Billing Considerations

Document any overlap with systemic autoimmune diseases.

Coding Guidelines

Inclusion Criteria

Use D59.12 When
  • Follow official coding guidelines for autoimmune conditions, ensuring accurate documentation of the hemolytic process and any underlying causes
  • Include relevant lab findings and patient history

Exclusion Criteria

Do NOT use D59.12 When
No specific exclusions found.

Related ICD-10 Codes

Related CPT Codes

85025CPT Code

Complete blood count (CBC) with reticulocyte count

Clinical Scenario

Used to assess anemia severity and reticulocyte response.

Documentation Requirements

Document the reason for the CBC and any relevant findings.

Specialty Considerations

Hematology specialists should ensure all lab results are clearly linked to the diagnosis.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of autoimmune hemolytic anemias, improving the accuracy of diagnoses and treatment tracking. D59.12 provides a clear distinction from other types of hemolytic anemia, facilitating better patient management.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of autoimmune hemolytic anemias, improving the accuracy of diagnoses and treatment tracking. D59.12 provides a clear distinction from other types of hemolytic anemia, facilitating better patient management.

Reimbursement & Billing Impact

The transition to ICD-10 has allowed for more specific coding of autoimmune hemolytic anemias, improving the accuracy of diagnoses and treatment tracking. D59.12 provides a clear distinction from other types of hemolytic anemia, facilitating better patient management.

Resources

Clinical References

  • •
    American Society of Hematology

Coding & Billing References

  • •
    American Society of Hematology

Frequently Asked Questions

What are the common symptoms of cold autoimmune hemolytic anemia?

Common symptoms include fatigue, pallor, jaundice, and splenomegaly, often exacerbated by exposure to cold temperatures.

How is cold autoimmune hemolytic anemia diagnosed?

Diagnosis is typically confirmed through a positive direct Coombs test, along with laboratory findings such as elevated LDH and decreased haptoglobin.