Hemolytic-uremic syndrome
ICD-10 D59.3 is a billable code used to indicate a diagnosis of hemolytic-uremic syndrome.
Hemolytic-uremic syndrome (HUS) is a serious condition characterized by a triad of symptoms: hemolytic anemia, acute renal failure, and thrombocytopenia. It often occurs following an infection, particularly with certain strains of Escherichia coli (E. coli), such as O157:H7, which produce Shiga toxin. The syndrome primarily affects children but can occur in adults as well. The hemolytic component involves the destruction of red blood cells, leading to anemia, while the uremic aspect refers to the kidney failure that results from the damage to the renal microvasculature. Thrombocytopenia, or low platelet count, contributes to the risk of bleeding. The pathophysiology of HUS involves endothelial injury, which triggers a cascade of events leading to microangiopathic hemolytic anemia and renal impairment. Diagnosis is typically confirmed through clinical evaluation, laboratory tests showing anemia, elevated creatinine levels, and low platelet counts. Management focuses on supportive care, including hydration, blood transfusions, and dialysis if necessary. Early recognition and treatment are crucial to improving outcomes.
Detailed clinical history, laboratory results, and treatment plans.
Children presenting with diarrhea followed by signs of anemia and renal failure.
Consideration of age-related factors in symptom presentation and management.
Comprehensive renal function tests, imaging studies, and treatment response documentation.
Patients with acute kidney injury following gastrointestinal infections.
Focus on renal recovery and long-term follow-up care.
Used in cases of severe anemia associated with HUS.
Document indication for transfusion and patient response.
Pediatric considerations for transfusion thresholds.
The key symptoms include hemolytic anemia, acute renal failure, and thrombocytopenia, often following a gastrointestinal infection.
