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ICD-10 Guide
ICD-10 CodesD59.6

D59.6

Billable

Hemoglobinuria due to hemolysis from other external causes

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/05/2025

Code Description

ICD-10 D59.6 is a billable code used to indicate a diagnosis of hemoglobinuria due to hemolysis from other external causes.

Key Diagnostic Point:

Hemoglobinuria is the presence of hemoglobin in the urine, which can occur due to hemolysis, the breakdown of red blood cells. In cases classified under D59.6, hemolysis is attributed to external causes such as trauma, infections, or exposure to certain toxins. This condition can arise from various hemolytic anemias, including autoimmune hemolytic anemia, where the body's immune system mistakenly attacks its own red blood cells. Enzyme deficiencies, such as glucose-6-phosphate dehydrogenase (G6PD) deficiency, can also lead to hemolysis, particularly after exposure to certain drugs or foods. Thalassemias and sickle cell disease are genetic disorders that can predispose individuals to hemolysis, resulting in hemoglobinuria. The clinical presentation may include dark-colored urine, fatigue, and signs of anemia. Accurate diagnosis often requires laboratory tests to confirm hemolysis and rule out other causes of hemoglobinuria. Understanding the underlying causes is crucial for effective management and treatment.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Differentiating between various causes of hemolysis
  • Understanding the relationship between hemolytic anemias and hemoglobinuria
  • Identifying external factors contributing to hemolysis
  • Navigating documentation requirements for multiple specialties

Audit Risk Factors

  • Inadequate documentation of external causes of hemolysis
  • Failure to specify the type of hemolytic anemia present
  • Misclassification of hemoglobinuria as a primary condition
  • Lack of supporting lab results for hemolysis

Specialty Focus

Medical Specialties

Hematology

Documentation Requirements

Detailed lab results indicating hemolysis, patient history, and treatment plans.

Common Clinical Scenarios

Patients presenting with fatigue, jaundice, and dark urine; management of chronic hemolytic anemia.

Billing Considerations

Ensure all lab findings are documented to support the diagnosis of hemoglobinuria.

Emergency Medicine

Documentation Requirements

Immediate assessment findings, lab results, and treatment interventions.

Common Clinical Scenarios

Acute presentations of hemoglobinuria following trauma or drug exposure.

Billing Considerations

Timely documentation is critical for accurate coding and billing.

Coding Guidelines

Inclusion Criteria

Use D59.6 When
  • According to ICD
  • 10 coding guidelines, D59
  • 6 should be used when hemoglobinuria is specifically due to hemolysis from external causes
  • Coders must ensure that the documentation clearly supports the diagnosis and that all relevant external factors are noted

Exclusion Criteria

Do NOT use D59.6 When
No specific exclusions found.

Related ICD-10 Codes

Related CPT Codes

85025CPT Code

Complete blood count (CBC) with automated differential

Clinical Scenario

Used to evaluate hemolysis and anemia in patients with hemoglobinuria.

Documentation Requirements

Document the indication for the CBC and any relevant clinical findings.

Specialty Considerations

Hematologists may require additional tests to assess hemolysis.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of hemoglobinuria due to external causes, improving the accuracy of diagnoses and treatment plans. This specificity aids in better tracking of hemolytic conditions and their management.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of hemoglobinuria due to external causes, improving the accuracy of diagnoses and treatment plans. This specificity aids in better tracking of hemolytic conditions and their management.

Reimbursement & Billing Impact

The transition to ICD-10 has allowed for more specific coding of hemoglobinuria due to external causes, improving the accuracy of diagnoses and treatment plans. This specificity aids in better tracking of hemolytic conditions and their management.

Resources

Clinical References

  • •
    ICD-10-CM Official Guidelines for Coding and Reporting

Coding & Billing References

  • •
    ICD-10-CM Official Guidelines for Coding and Reporting

Frequently Asked Questions

What are the common causes of hemoglobinuria?

Common causes include hemolytic anemias, infections, trauma, and exposure to certain toxins or drugs that can lead to hemolysis.