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ICD-10 Guide
ICD-10 CodesD59.8

D59.8

Billable

Other acquired hemolytic anemias

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/05/2025

Code Description

ICD-10 D59.8 is a billable code used to indicate a diagnosis of other acquired hemolytic anemias.

Key Diagnostic Point:

Acquired hemolytic anemias are a group of disorders characterized by the premature destruction of red blood cells (RBCs), leading to anemia. Unlike hereditary forms of hemolytic anemia, acquired types can arise from various external factors, including autoimmune diseases, infections, certain medications, and exposure to toxins. In autoimmune hemolytic anemia (AIHA), the body's immune system mistakenly attacks its own RBCs, often triggered by conditions such as lupus or lymphoproliferative disorders. Enzyme deficiencies, such as glucose-6-phosphate dehydrogenase (G6PD) deficiency, can also lead to hemolysis, particularly in response to oxidative stress. Thalassemias and sickle cell disease are primarily genetic disorders, but they can also present with acquired features due to environmental factors or complications. Accurate diagnosis often requires a combination of clinical evaluation, laboratory tests, and sometimes bone marrow examination. Treatment may involve addressing the underlying cause, such as discontinuing a causative medication or managing an autoimmune condition, and may include transfusions or immunosuppressive therapy. Understanding the nuances of acquired hemolytic anemias is crucial for effective management and coding.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Variety of underlying causes leading to hemolytic anemia.
  • Need for comprehensive clinical documentation to establish the diagnosis.
  • Differentiation from hereditary hemolytic anemias.
  • Potential overlap with other anemia codes.

Audit Risk Factors

  • Inadequate documentation of the underlying cause of hemolysis.
  • Failure to specify the type of acquired hemolytic anemia.
  • Misclassification with hereditary hemolytic anemias.
  • Lack of supporting lab results or clinical findings.

Specialty Focus

Medical Specialties

Hematology

Documentation Requirements

Detailed lab results, patient history, and treatment plans.

Common Clinical Scenarios

Diagnosis and management of autoimmune hemolytic anemia, G6PD deficiency episodes.

Billing Considerations

Ensure clear documentation of the hemolytic process and any associated conditions.

Internal Medicine

Documentation Requirements

Comprehensive patient history, medication review, and lab findings.

Common Clinical Scenarios

Management of patients with anemia due to chronic disease or drug-induced hemolysis.

Billing Considerations

Document any potential triggers or underlying conditions contributing to hemolysis.

Coding Guidelines

Inclusion Criteria

Use D59.8 When
  • Follow official coding guidelines for hemolytic anemias, ensuring to document the specific type of acquired hemolytic anemia
  • Include any relevant lab results and clinical findings that support the diagnosis

Exclusion Criteria

Do NOT use D59.8 When
  • Exclude hereditary forms unless specified

Related ICD-10 Codes

Related CPT Codes

85025CPT Code

Complete blood count (CBC) with automated differential

Clinical Scenario

Used to evaluate anemia and hemolysis.

Documentation Requirements

Document the reason for the CBC and any relevant findings.

Specialty Considerations

Hematology specialists may require additional tests based on initial findings.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of acquired hemolytic anemias, improving the ability to capture the nuances of these conditions and their underlying causes, which can enhance patient care and reimbursement accuracy.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of acquired hemolytic anemias, improving the ability to capture the nuances of these conditions and their underlying causes, which can enhance patient care and reimbursement accuracy.

Reimbursement & Billing Impact

reimbursement accuracy.

Resources

Clinical References

  • •
    American Society of Hematology

Coding & Billing References

  • •
    American Society of Hematology

Frequently Asked Questions

What are the common causes of acquired hemolytic anemia?

Common causes include autoimmune disorders, infections, certain medications, and exposure to toxins. Each cause may require different management strategies.