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ICD-10 Guide
ICD-10 CodesD64.2

D64.2

Billable

Secondary sideroblastic anemia due to drugs and toxins

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/05/2025

Code Description

ICD-10 D64.2 is a billable code used to indicate a diagnosis of secondary sideroblastic anemia due to drugs and toxins.

Key Diagnostic Point:

Secondary sideroblastic anemia is a type of anemia characterized by the presence of ringed sideroblasts in the bone marrow, which are erythroblasts that contain iron granules. This condition arises as a result of exposure to certain drugs and toxins that interfere with hemoglobin synthesis. Common culprits include alcohol, lead, and various chemotherapeutic agents. Patients may present with symptoms of anemia such as fatigue, pallor, and shortness of breath. The diagnosis is confirmed through a combination of clinical evaluation, blood tests showing microcytic anemia, and a bone marrow biopsy revealing the characteristic sideroblasts. Treatment focuses on removing the offending agent and may include supportive care such as blood transfusions or iron chelation therapy if iron overload occurs. Understanding the underlying cause is crucial for effective management and prevention of further complications.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Requires knowledge of specific drugs and toxins that can cause sideroblastic anemia.
  • Differentiation from other types of anemia, such as iron deficiency anemia.
  • Need for accurate documentation of drug history and exposure.
  • Potential for overlapping symptoms with other hematologic disorders.

Audit Risk Factors

  • Inadequate documentation of drug exposure.
  • Failure to document the presence of ringed sideroblasts.
  • Misclassification of anemia type.
  • Lack of follow-up documentation on treatment response.

Specialty Focus

Medical Specialties

Hematology

Documentation Requirements

Detailed patient history including medication use, laboratory results, and bone marrow biopsy findings.

Common Clinical Scenarios

Patients presenting with unexplained anemia and a history of drug exposure.

Billing Considerations

Ensure all relevant lab results and treatment plans are documented to support the diagnosis.

Oncology

Documentation Requirements

Documentation of chemotherapy regimens and any associated toxicities.

Common Clinical Scenarios

Patients undergoing treatment for malignancies who develop anemia.

Billing Considerations

Monitor for potential drug interactions and cumulative toxicity.

Coding Guidelines

Inclusion Criteria

Use D64.2 When
  • Follow the official ICD
  • CM coding guidelines for coding anemia, ensuring to document the cause as secondary to drugs and toxins
  • Include any relevant lab findings and patient history

Exclusion Criteria

Do NOT use D64.2 When
No specific exclusions found.

Related ICD-10 Codes

Related CPT Codes

85025CPT Code

Complete blood count (CBC) with differential

Clinical Scenario

Used to evaluate anemia and monitor treatment response.

Documentation Requirements

Document the reason for the CBC and any relevant findings.

Specialty Considerations

Hematology specialists should ensure all relevant lab results are included.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of secondary anemias, including D64.2, which improves data accuracy and enhances the ability to track and manage these conditions effectively.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of secondary anemias, including D64.2, which improves data accuracy and enhances the ability to track and manage these conditions effectively.

Reimbursement & Billing Impact

The transition to ICD-10 has allowed for more specific coding of secondary anemias, including D64.2, which improves data accuracy and enhances the ability to track and manage these conditions effectively.

Resources

Clinical References

  • •
    American Society of Hematology

Coding & Billing References

  • •
    American Society of Hematology

Frequently Asked Questions

What are the common causes of secondary sideroblastic anemia?

Common causes include exposure to certain drugs (like chloramphenicol, isoniazid), toxins (like lead), and alcohol abuse. Identifying the specific cause is crucial for treatment.