Activated protein C resistance
ICD-10 D68.51 is a billable code used to indicate a diagnosis of activated protein c resistance.
Activated protein C resistance (APCR) is a coagulation defect characterized by the body's inability to effectively regulate blood clotting due to a deficiency or dysfunction of activated protein C (APC). This condition is often associated with Factor V Leiden mutation, which leads to an increased risk of venous thromboembolism (VTE). Patients with APCR may present with recurrent thrombosis, particularly in the deep veins of the legs (deep vein thrombosis) or pulmonary arteries (pulmonary embolism). The condition can manifest in various clinical scenarios, including during pregnancy, surgery, or in the presence of other risk factors such as obesity or prolonged immobility. Diagnosis typically involves specialized coagulation tests, including the activated protein C resistance assay, which measures the response of a patient's plasma to APC. Management may include anticoagulation therapy, especially in patients with a history of thrombosis. Understanding APCR is crucial for healthcare providers to prevent serious complications associated with thrombosis and to guide appropriate treatment strategies.
Detailed lab results, patient history of thrombotic events, and treatment plans.
Patients presenting with recurrent thrombosis, especially in young adults.
Ensure clear documentation of the relationship between APCR and any thrombotic events.
History of APCR in pregnant patients, management plans during pregnancy.
Pregnant patients with a history of thrombosis or APCR.
Document the implications of APCR on pregnancy management and delivery.
Used to confirm diagnosis of APCR in patients with a history of thrombosis.
Document the indication for testing and any relevant clinical history.
Hematology specialists should ensure comprehensive documentation of test results.
The primary cause of activated protein C resistance is the Factor V Leiden mutation, which leads to a hypercoagulable state and increased risk of thrombosis.
