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ICD-10 Guide
ICD-10 CodesD68.61

D68.61

Billable

Antiphospholipid syndrome

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/05/2025

Code Description

ICD-10 D68.61 is a billable code used to indicate a diagnosis of antiphospholipid syndrome.

Key Diagnostic Point:

Antiphospholipid syndrome (APS) is an autoimmune disorder characterized by the presence of antiphospholipid antibodies (aPL) that lead to an increased risk of thrombosis and pregnancy-related complications. Patients with APS may experience recurrent venous or arterial thrombosis, which can manifest as deep vein thrombosis, pulmonary embolism, stroke, or myocardial infarction. Additionally, women with APS may face obstetric complications such as recurrent miscarriages, stillbirth, or preeclampsia. The syndrome is often associated with other autoimmune diseases, particularly systemic lupus erythematosus (SLE). Diagnosis typically involves laboratory tests to detect aPL, including lupus anticoagulant, anticardiolipin antibodies, and anti-beta-2 glycoprotein I antibodies. Management of APS focuses on anticoagulation therapy to prevent thrombotic events, with options including warfarin and low molecular weight heparin. The complexity of APS arises from its variable clinical presentation, the need for careful monitoring of anticoagulation therapy, and the potential for overlapping conditions such as thrombocytopenia and other bleeding disorders.

Code Complexity Analysis

Complexity Rating: High

High Complexity

Complexity Factors

  • Variable clinical presentation and symptoms
  • Need for comprehensive laboratory testing
  • Management may involve multiple specialties
  • Potential overlap with other autoimmune disorders

Audit Risk Factors

  • Inadequate documentation of laboratory test results
  • Failure to document the clinical rationale for anticoagulation therapy
  • Misclassification of symptoms related to APS
  • Inconsistent coding of associated conditions

Specialty Focus

Medical Specialties

Rheumatology

Documentation Requirements

Detailed history of autoimmune symptoms, laboratory test results, and treatment plans.

Common Clinical Scenarios

Diagnosis and management of APS in patients with SLE or other autoimmune disorders.

Billing Considerations

Ensure clear documentation of the relationship between APS and any coexisting conditions.

Hematology

Documentation Requirements

Comprehensive records of coagulation profiles, treatment regimens, and monitoring of anticoagulation therapy.

Common Clinical Scenarios

Management of thrombotic events in patients with APS.

Billing Considerations

Document any changes in anticoagulation therapy and patient response.

Coding Guidelines

Inclusion Criteria

Use D68.61 When
  • According to ICD
  • 10 coding guidelines, D68
  • 61 should be used when a patient has a confirmed diagnosis of antiphospholipid syndrome with documented laboratory evidence of antiphospholipid antibodies
  • It is important to document any associated conditions, such as thrombosis or pregnancy complications, to ensure accurate coding

Exclusion Criteria

Do NOT use D68.61 When
No specific exclusions found.

Related ICD-10 Codes

Related CPT Codes

85025CPT Code

Complete blood count (CBC) with platelet count

Clinical Scenario

Used to monitor platelet levels in patients with APS.

Documentation Requirements

Document the reason for the CBC and any relevant clinical findings.

Specialty Considerations

Rheumatologists and hematologists should ensure that the CBC results are linked to the management of APS.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of antiphospholipid syndrome, improving the accuracy of data collection and reimbursement processes. This specificity aids in better understanding the epidemiology and management of the condition.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of antiphospholipid syndrome, improving the accuracy of data collection and reimbursement processes. This specificity aids in better understanding the epidemiology and management of the condition.

Reimbursement & Billing Impact

reimbursement processes. This specificity aids in better understanding the epidemiology and management of the condition.

Resources

Clinical References

  • •
    Antiphospholipid Syndrome Foundation

Coding & Billing References

  • •
    Antiphospholipid Syndrome Foundation

Frequently Asked Questions

What are the common symptoms of antiphospholipid syndrome?

Common symptoms include recurrent thrombosis, pregnancy complications, and sometimes thrombocytopenia. Patients may also experience symptoms related to underlying autoimmune conditions.