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v1.0.0
ICD-10 Guide
ICD-10 CodesD70.1

D70.1

Billable

Agranulocytosis secondary to cancer chemotherapy

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/05/2025

Code Description

ICD-10 D70.1 is a billable code used to indicate a diagnosis of agranulocytosis secondary to cancer chemotherapy.

Key Diagnostic Point:

Agranulocytosis is a severe form of neutropenia characterized by an extremely low level of neutrophils, a type of white blood cell essential for fighting off infections. This condition can occur as a side effect of cancer chemotherapy, which often targets rapidly dividing cells, including those in the bone marrow responsible for producing neutrophils. Patients undergoing chemotherapy may experience a significant drop in their white blood cell count, leading to increased susceptibility to infections, fever, and other complications. The risk of agranulocytosis varies depending on the type of chemotherapy regimen, the dosage, and the individual patient's response. Monitoring of blood counts is crucial during treatment, and patients may require interventions such as growth factor support or antibiotics to manage the risk of infections. Understanding the underlying mechanisms of neutropenia and the impact of chemotherapy on bone marrow function is essential for effective management and coding of this condition.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Requires understanding of chemotherapy regimens and their side effects
  • Differentiation from other types of neutropenia
  • Need for precise documentation of chemotherapy history
  • Potential for concurrent infections complicating the diagnosis

Audit Risk Factors

  • Inadequate documentation of chemotherapy history
  • Failure to document concurrent infections
  • Misclassification of neutropenia type
  • Lack of follow-up blood count results

Specialty Focus

Medical Specialties

Oncology

Documentation Requirements

Detailed records of chemotherapy regimens, patient response, and blood count monitoring.

Common Clinical Scenarios

Patients experiencing febrile neutropenia post-chemotherapy, requiring hospitalization.

Billing Considerations

Ensure accurate coding of the specific chemotherapy agent and dosage.

Hematology

Documentation Requirements

Comprehensive blood work results and history of hematologic disorders.

Common Clinical Scenarios

Patients with pre-existing blood disorders undergoing chemotherapy.

Billing Considerations

Differentiating between primary and secondary causes of neutropenia.

Coding Guidelines

Inclusion Criteria

Use D70.1 When
  • According to ICD
  • 10 guidelines, D70
  • 1 should be used when agranulocytosis is directly linked to chemotherapy
  • Coders must ensure that the chemotherapy treatment is documented and that the agranulocytosis is not due to other causes

Exclusion Criteria

Do NOT use D70.1 When
No specific exclusions found.

Related ICD-10 Codes

Related CPT Codes

85025CPT Code

Complete blood count (CBC) with differential

Clinical Scenario

Used to monitor blood counts in patients undergoing chemotherapy.

Documentation Requirements

Document the reason for the CBC and the results.

Specialty Considerations

Oncology specialists should ensure that CBC results are linked to chemotherapy treatment.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of agranulocytosis, enabling better tracking of chemotherapy-related complications and improving patient care management.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of agranulocytosis, enabling better tracking of chemotherapy-related complications and improving patient care management.

Reimbursement & Billing Impact

The transition to ICD-10 has allowed for more specific coding of agranulocytosis, enabling better tracking of chemotherapy-related complications and improving patient care management.

Resources

Clinical References

  • •
    ICD-10-CM Official Guidelines for Coding and Reporting

Coding & Billing References

  • •
    ICD-10-CM Official Guidelines for Coding and Reporting

Frequently Asked Questions

What is the primary cause of agranulocytosis in patients undergoing chemotherapy?

The primary cause is the suppression of bone marrow function due to cytotoxic effects of chemotherapy agents, leading to a significant decrease in neutrophil production.