Genetic anomalies of leukocytes
ICD-10 D72.0 is a billable code used to indicate a diagnosis of genetic anomalies of leukocytes.
Genetic anomalies of leukocytes, classified under ICD-10 code D72.0, encompass a range of inherited disorders that affect the production, function, and morphology of white blood cells (leukocytes). These anomalies can lead to various hematological conditions, including neutropenia, where there is a decreased number of neutrophils, increasing susceptibility to infections. Patients may present with recurrent infections, delayed wound healing, and other immunodeficiencies. The genetic basis of these disorders can involve mutations in genes responsible for leukocyte development and function, leading to abnormalities in the immune response. Disorders such as congenital neutropenia, cyclic neutropenia, and other leukocyte disorders may be included under this code. Additionally, splenic disorders can complicate these conditions, as the spleen plays a crucial role in filtering blood and managing immune responses. Accurate diagnosis often requires a combination of clinical evaluation, family history, and laboratory tests, including complete blood counts and genetic testing.
Detailed laboratory results, genetic testing reports, and clinical notes on patient history and symptoms.
Patients presenting with recurrent infections, unexplained fevers, or abnormal blood counts.
Ensure that all genetic testing and family history are thoroughly documented to support the diagnosis.
Immunological assessments, history of infections, and response to treatments.
Patients with autoimmune disorders or recurrent infections due to leukocyte dysfunction.
Document any immunodeficiencies and their impact on patient health.
Used to evaluate white blood cell counts in patients suspected of having leukocyte disorders.
Document the reason for the CBC and any relevant clinical findings.
Hematologists should ensure that results are interpreted in the context of genetic testing.
Common genetic anomalies include mutations in genes such as ELANE, which is associated with congenital neutropenia, and other inherited conditions affecting leukocyte function.
