Hypereosinophilic syndrome [HES]
ICD-10 D72.11 is a billable code used to indicate a diagnosis of hypereosinophilic syndrome [hes].
Hypereosinophilic syndrome (HES) is characterized by an elevated eosinophil count in the blood, typically exceeding 1,500 eosinophils per microliter, for an extended period, often without an identifiable cause. This condition can lead to significant organ damage due to the infiltration of eosinophils into various tissues, including the skin, lungs, heart, and gastrointestinal tract. Patients may present with symptoms such as fever, fatigue, weight loss, and respiratory issues. HES can be classified into primary (or idiopathic), secondary (due to other conditions such as infections, malignancies, or autoimmune diseases), and familial forms. The pathophysiology involves dysregulation of eosinophil production and survival, often linked to cytokine imbalances. Diagnosis typically requires a thorough clinical evaluation, including blood tests, imaging studies, and sometimes bone marrow biopsy to rule out other hematological disorders. Management may involve corticosteroids, immunosuppressive agents, or targeted therapies depending on the severity and underlying cause of the eosinophilia.
Complete blood count (CBC) with differential, detailed patient history, and any relevant imaging or biopsy results.
Patients presenting with unexplained eosinophilia, symptoms of organ involvement, or those requiring treatment for HES.
Ensure clear documentation of eosinophil counts and any associated symptoms or complications.
Immunological workup to rule out secondary causes, including autoimmune disorders.
Patients with recurrent infections or autoimmune symptoms alongside eosinophilia.
Document any immunodeficiencies or related conditions that may complicate the diagnosis.
Used to monitor eosinophil levels in patients diagnosed with HES.
Document the reason for the CBC and any relevant clinical findings.
Hematology specialists should ensure accurate interpretation of eosinophil counts.
The primary cause of HES is often unknown, but it can be associated with genetic mutations, autoimmune diseases, or malignancies. It is essential to rule out secondary causes before diagnosing primary HES.
