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ICD-10 Guide
ICD-10 CodesD72.81

D72.81

Billable

Decreased white blood cell count

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/05/2025

Code Description

ICD-10 D72.81 is a billable code used to indicate a diagnosis of decreased white blood cell count.

Key Diagnostic Point:

Decreased white blood cell count, or leukopenia, is a condition characterized by a lower than normal number of white blood cells (WBCs) in the bloodstream. This condition can result from various factors, including bone marrow disorders, autoimmune diseases, infections, and certain medications. Neutropenia, a specific type of leukopenia, refers to a decrease in neutrophils, which are crucial for fighting infections. Patients with neutropenia are at increased risk for infections, and the severity of the condition can vary based on the absolute neutrophil count (ANC). Disorders of the spleen, such as splenomegaly or hypersplenism, can also contribute to decreased WBC counts by sequestering blood cells. Additionally, immunodeficiencies, whether congenital or acquired, can lead to leukopenia as the immune system fails to produce adequate white blood cells. Clinicians must evaluate the underlying cause of decreased WBC counts to determine appropriate management and treatment strategies, which may include addressing the underlying condition, administering growth factors, or adjusting medications.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Variety of underlying causes requiring thorough documentation
  • Differentiation between types of leukopenia (e.g., neutropenia vs. lymphopenia)
  • Potential for concurrent conditions affecting WBC counts
  • Need for precise lab results to support diagnosis

Audit Risk Factors

  • Inadequate documentation of the underlying cause of leukopenia
  • Failure to specify the type of leukopenia (e.g., neutropenia)
  • Lack of supporting lab results for diagnosis
  • Misuse of the code in the absence of a confirmed diagnosis

Specialty Focus

Medical Specialties

Hematology

Documentation Requirements

Detailed lab results, patient history, and treatment plans must be documented.

Common Clinical Scenarios

Patients presenting with unexplained infections, fatigue, or abnormal lab results.

Billing Considerations

Consideration of bone marrow biopsy results and other diagnostic tests to determine the cause of leukopenia.

Oncology

Documentation Requirements

Documentation of cancer treatment regimens and their effects on blood counts.

Common Clinical Scenarios

Patients undergoing chemotherapy presenting with neutropenia.

Billing Considerations

Monitoring for febrile neutropenia and the need for growth factor support.

Coding Guidelines

Inclusion Criteria

Use D72.81 When
  • According to ICD
  • 10 coding guidelines, D72
  • 81 should be used when a patient has a documented decrease in white blood cell count
  • Coders must ensure that the diagnosis is supported by laboratory results and that the underlying cause is clearly documented

Exclusion Criteria

Do NOT use D72.81 When
  • Exclusion criteria include conditions that do not specifically relate to leukopenia

Related ICD-10 Codes

Related CPT Codes

85025CPT Code

Complete blood count (CBC) with differential

Clinical Scenario

Used to evaluate a patient presenting with symptoms of infection and suspected leukopenia.

Documentation Requirements

Document the reason for the CBC and any relevant clinical findings.

Specialty Considerations

Hematologists may require additional tests based on CBC results.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of leukopenia, enabling better tracking of patient outcomes and more precise reimbursement for healthcare providers. D72.81 provides a clear designation for decreased white blood cell counts, facilitating improved clinical management.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of leukopenia, enabling better tracking of patient outcomes and more precise reimbursement for healthcare providers. D72.81 provides a clear designation for decreased white blood cell counts, facilitating improved clinical management.

Reimbursement & Billing Impact

reimbursement for healthcare providers. D72.81 provides a clear designation for decreased white blood cell counts, facilitating improved clinical management.

Resources

Clinical References

  • •
    ICD-10-CM Official Guidelines for Coding and Reporting

Coding & Billing References

  • •
    ICD-10-CM Official Guidelines for Coding and Reporting

Frequently Asked Questions

What are the common causes of decreased white blood cell count?

Common causes include bone marrow disorders, autoimmune diseases, infections, certain medications, and splenic disorders. Each cause may require different management strategies.