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ICD-10 Guide
ICD-10 CodesD72.821

D72.821

Billable

Monocytosis (symptomatic)

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/05/2025

Code Description

ICD-10 D72.821 is a billable code used to indicate a diagnosis of monocytosis (symptomatic).

Key Diagnostic Point:

Monocytosis refers to an elevated level of monocytes in the blood, which can be symptomatic of various underlying conditions. Monocytes are a type of white blood cell that play a crucial role in the immune response, particularly in the phagocytosis of pathogens and the regulation of inflammation. Symptomatic monocytosis may indicate chronic infections, autoimmune disorders, or hematological malignancies. It is often associated with other white blood cell disorders, such as neutropenia, where there is a deficiency of neutrophils, leading to increased susceptibility to infections. Additionally, monocytosis can be linked to spleen disorders, as the spleen is involved in the production and regulation of blood cells. Immunodeficiencies may also present with monocytosis, as the body attempts to compensate for the lack of effective immune response. Accurate diagnosis and coding require a thorough understanding of the patient's clinical history and laboratory findings, as monocytosis can be a marker for serious underlying health issues.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Differentiating between primary and secondary causes of monocytosis
  • Understanding the relationship with other hematological conditions
  • Interpreting laboratory results accurately
  • Documenting associated symptoms and comorbidities

Audit Risk Factors

  • Inadequate documentation of symptoms
  • Failure to link monocytosis to underlying conditions
  • Misinterpretation of laboratory results
  • Inconsistent coding practices across providers

Specialty Focus

Medical Specialties

Hematology

Documentation Requirements

Detailed lab results, patient history, and treatment plans must be documented.

Common Clinical Scenarios

Patients presenting with unexplained fatigue, recurrent infections, or abnormal blood counts.

Billing Considerations

Ensure that the relationship between monocytosis and any hematological malignancies is clearly documented.

Immunology

Documentation Requirements

Comprehensive immunological assessments and patient history regarding autoimmune disorders.

Common Clinical Scenarios

Patients with autoimmune diseases presenting with elevated monocyte levels.

Billing Considerations

Document any immunodeficiencies that may contribute to monocytosis.

Coding Guidelines

Inclusion Criteria

Use D72.821 When
  • Follow the official ICD
  • CM coding guidelines, ensuring that the code is used when monocytosis is symptomatic and linked to specific clinical conditions

Exclusion Criteria

Do NOT use D72.821 When
  • Exclude cases where monocytosis is incidental or not symptomatic

Related ICD-10 Codes

Related CPT Codes

85025CPT Code

Complete blood count (CBC) with differential

Clinical Scenario

Used to evaluate white blood cell counts, including monocyte levels.

Documentation Requirements

Document the reason for the CBC and any relevant clinical findings.

Specialty Considerations

Hematologists may require additional tests based on CBC results.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of conditions like monocytosis, improving the accuracy of diagnoses and treatment plans. It has also enhanced the ability to track epidemiological trends related to white blood cell disorders.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of conditions like monocytosis, improving the accuracy of diagnoses and treatment plans. It has also enhanced the ability to track epidemiological trends related to white blood cell disorders.

Reimbursement & Billing Impact

The transition to ICD-10 has allowed for more specific coding of conditions like monocytosis, improving the accuracy of diagnoses and treatment plans. It has also enhanced the ability to track epidemiological trends related to white blood cell disorders.

Resources

Clinical References

  • •
    ICD-10-CM Official Guidelines for Coding and Reporting

Coding & Billing References

  • •
    ICD-10-CM Official Guidelines for Coding and Reporting

Frequently Asked Questions

What is the significance of monocytosis?

Monocytosis can indicate underlying health issues such as chronic infections, autoimmune diseases, or hematological malignancies. It is important to evaluate the context in which monocytosis occurs to determine the appropriate management.