Non-immune heparin-induced thrombocytopenia
ICD-10 D75.821 is a billable code used to indicate a diagnosis of non-immune heparin-induced thrombocytopenia.
Non-immune heparin-induced thrombocytopenia (HIT) is a condition characterized by a decrease in platelet count following heparin administration, without the presence of antibodies typically associated with immune-mediated HIT. This condition can occur in patients receiving heparin for various medical conditions, including venous thromboembolism and during surgical procedures. The pathophysiology involves the activation of platelets by heparin, leading to their consumption and subsequent thrombocytopenia. Clinically, patients may present with a drop in platelet count, often more than 50% from baseline, and may experience thrombotic complications despite low platelet levels. Diagnosis is primarily based on clinical criteria and laboratory tests to rule out immune-mediated HIT. Management includes discontinuation of heparin and consideration of alternative anticoagulants. Monitoring of platelet counts is essential to ensure patient safety and to guide further treatment decisions.
Detailed clinical history, laboratory results, and treatment plans.
Patients presenting with thrombocytopenia post-heparin therapy.
Ensure clear documentation of the timeline of heparin administration and platelet count monitoring.
Comprehensive patient history and medication review.
Management of patients on anticoagulation therapy with unexpected thrombocytopenia.
Document any alternative anticoagulants used and the rationale for their selection.
Used to monitor platelet levels in patients suspected of HIT.
Document the reason for the CBC and any relevant clinical findings.
Hematologists may require additional tests to confirm diagnosis.
The primary cause is the activation of platelets by heparin, leading to their consumption and a subsequent drop in platelet count, without the presence of antibodies.
