Combined immunodeficiencies
Chapter 3:Diseases of the blood and blood-forming organs
ICD-10 D81 is a billable code used to indicate a diagnosis of combined immunodeficiencies.
Combined immunodeficiencies (D81) refer to a group of disorders characterized by the simultaneous impairment of both humoral and cellular immunity. These conditions can lead to increased susceptibility to infections, autoimmune diseases, and malignancies. The immunodeficiencies can be congenital or acquired, with congenital forms often resulting from genetic mutations affecting immune system development. Patients may present with recurrent infections, failure to thrive, and other systemic complications. Diagnosis typically involves immunological assessments, including serum immunoglobulin levels, lymphocyte counts, and functional assays to evaluate immune response. Management may include immunoglobulin replacement therapy, prophylactic antibiotics, and in some cases, hematopoietic stem cell transplantation. The complexity of these disorders necessitates a multidisciplinary approach involving immunologists, hematologists, and other specialists to ensure comprehensive care and management of associated complications.
Detailed immunological assessment results, including immunoglobulin levels and lymphocyte subsets.
Patients presenting with recurrent infections, failure to thrive, or autoimmune manifestations.
Ensure all immunological tests are documented and correlate with clinical findings.
Complete blood counts, bone marrow biopsy results, and any relevant genetic testing.
Patients with hematological manifestations of immunodeficiency, such as lymphopenia or cytopenias.
Document any hematological complications and their management thoroughly.
Used for obtaining blood samples for immunological testing.
Document the reason for blood collection and any relevant patient history.
Ensure that the specialty performing the test is clearly indicated.
Common symptoms include recurrent infections, failure to thrive, autoimmune disorders, and increased susceptibility to certain cancers. Patients may experience frequent respiratory infections, gastrointestinal infections, and skin infections.
