Severe combined immunodeficiency [SCID] with low T- and B-cell numbers
ICD-10 D81.1 is a billable code used to indicate a diagnosis of severe combined immunodeficiency [scid] with low t- and b-cell numbers.
Severe combined immunodeficiency (SCID) is a rare genetic disorder characterized by a profound deficiency in both T- and B-lymphocytes, leading to a severely compromised immune system. Individuals with SCID are highly susceptible to infections, including opportunistic pathogens, due to the lack of functional immune responses. The condition is often diagnosed in infancy, typically presenting with recurrent infections, failure to thrive, and chronic diarrhea. Laboratory findings reveal markedly low levels of T-cells and B-cells, which are critical for adaptive immunity. Genetic mutations affecting lymphocyte development, such as those in the IL2RG gene, are commonly implicated. Management of SCID includes protective isolation, prophylactic antibiotics, and definitive treatments such as hematopoietic stem cell transplantation (HSCT). Early diagnosis and intervention are crucial for improving outcomes and survival rates in affected individuals.
Detailed history of recurrent infections, growth parameters, and immunologic evaluations.
Infants presenting with failure to thrive and recurrent infections.
Documentation must include specific immunologic test results and any genetic testing performed.
Comprehensive immunologic profile, including T-cell and B-cell counts, and genetic testing results.
Patients with a family history of immunodeficiency or presenting with unusual infections.
Accurate coding requires detailed lab results and clinical correlation with symptoms.
Used for diagnostic evaluation of hematologic conditions in SCID patients.
Document indication for aspiration and findings.
Pediatric hematology may require additional documentation for age-specific considerations.
Common symptoms include recurrent infections, failure to thrive, chronic diarrhea, and skin rashes. These symptoms typically present in infancy.
