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ICD-10 Guide
ICD-10 CodesChapter 3: Diseases of the blood and blood-forming organsD82

D82

Billable

Immunodeficiency associated with other major defects

Chapter 3:Diseases of the blood and blood-forming organs

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/05/2025

Code Description

ICD-10 D82 is a billable code used to indicate a diagnosis of immunodeficiency associated with other major defects.

Key Diagnostic Point:

D82 refers to a group of immunodeficiency disorders that are associated with significant structural or functional defects in other organ systems. These conditions can lead to a compromised immune response, making patients more susceptible to infections and other complications. The immunodeficiency may be secondary to congenital anomalies, such as those affecting the blood and blood-forming organs, or may arise from hematologic conditions like aplastic anemia or certain leukemias. Patients may present with recurrent infections, failure to thrive, and other systemic symptoms. The management of these patients often requires a multidisciplinary approach, including hematology, immunology, and sometimes genetics, to address both the immunodeficiency and the underlying defects. Accurate coding is essential for proper treatment planning and reimbursement, as well as for tracking epidemiological data related to these complex conditions.

Code Complexity Analysis

Complexity Rating: High

High Complexity

Complexity Factors

  • Variety of underlying conditions that can lead to immunodeficiency
  • Need for detailed clinical documentation to support the diagnosis
  • Potential overlap with other immunodeficiency codes
  • Complexity in distinguishing between primary and secondary immunodeficiencies

Audit Risk Factors

  • Inadequate documentation of associated defects
  • Misclassification of primary vs. secondary immunodeficiency
  • Failure to capture all relevant comorbidities
  • Inconsistent coding practices among different specialties

Specialty Focus

Medical Specialties

Hematology

Documentation Requirements

Detailed lab results, history of blood disorders, and treatment plans.

Common Clinical Scenarios

Patients with aplastic anemia presenting with recurrent infections.

Billing Considerations

Ensure that all hematologic conditions are documented to support the immunodeficiency diagnosis.

Immunology

Documentation Requirements

Comprehensive immune function tests and history of infections.

Common Clinical Scenarios

Patients with congenital immunodeficiencies requiring immunoglobulin therapy.

Billing Considerations

Document the specific immunologic tests performed and their results.

Coding Guidelines

Inclusion Criteria

Use D82 When
  • According to ICD
  • 10 guidelines, D82 should be used when the immunodeficiency is clearly linked to other major defects
  • Coders must ensure that documentation supports the diagnosis and that all relevant conditions are captured

Exclusion Criteria

Do NOT use D82 When
  • Exclusion criteria include primary immunodeficiencies that do not have associated major defects

Related CPT Codes

36415CPT Code

Collection of venous blood by venipuncture

Clinical Scenario

Used for laboratory tests to assess immune function.

Documentation Requirements

Document the reason for blood draw and tests ordered.

Specialty Considerations

Hematology and immunology specialties should ensure tests align with the diagnosis.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of immunodeficiency disorders, enabling better tracking of associated defects and improving the accuracy of claims and epidemiological data.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of immunodeficiency disorders, enabling better tracking of associated defects and improving the accuracy of claims and epidemiological data.

Reimbursement & Billing Impact

The transition to ICD-10 has allowed for more specific coding of immunodeficiency disorders, enabling better tracking of associated defects and improving the accuracy of claims and epidemiological data.

Resources

Clinical References

  • •
    ICD-10-CM Official Guidelines for Coding and Reporting

Coding & Billing References

  • •
    ICD-10-CM Official Guidelines for Coding and Reporting

Frequently Asked Questions

What is the difference between D81 and D82?

D81 codes are used for primary immunodeficiency disorders without associated major defects, while D82 is for immunodeficiencies linked to other significant structural or functional defects.