Common variable immunodeficiency
Chapter 3:Diseases of the blood and blood-forming organs
ICD-10 D83 is a billable code used to indicate a diagnosis of common variable immunodeficiency.
Common variable immunodeficiency (CVID) is a primary immunodeficiency disorder characterized by a significant reduction in serum immunoglobulin levels and an increased susceptibility to infections. Patients with CVID often present with recurrent bacterial infections, particularly of the respiratory and gastrointestinal tracts, due to impaired antibody production. The condition may also lead to autoimmune disorders, lymphoproliferative diseases, and an increased risk of malignancies. Diagnosis typically involves measuring serum immunoglobulin levels, assessing specific antibody responses, and ruling out other causes of hypogammaglobulinemia. The clinical presentation can vary widely among patients, with some experiencing mild symptoms while others may have severe complications. Treatment usually includes immunoglobulin replacement therapy and management of infections, along with monitoring for associated conditions. Given its complexity and the potential for overlapping symptoms with other immunodeficiencies, accurate coding and documentation are crucial for effective patient management and reimbursement.
Detailed immunological assessments, including serum immunoglobulin levels and specific antibody responses.
Patients presenting with recurrent infections, autoimmune disorders, or unexplained hypogammaglobulinemia.
Ensure comprehensive documentation of all immunological tests and patient history to support the diagnosis.
Complete blood counts, lymphocyte subsets, and any relevant bone marrow evaluations.
Patients with lymphoproliferative disorders or those requiring immunoglobulin therapy.
Document any hematological abnormalities that may coexist with CVID.
Used for patients with CVID receiving immunoglobulin therapy.
Document the indication for therapy and patient response.
Immunology specialists should ensure that the therapy aligns with the patient's immunodeficiency diagnosis.
Common symptoms include recurrent infections, particularly respiratory and gastrointestinal, autoimmune disorders, and an increased risk of certain cancers.
Diagnosis is based on low serum immunoglobulin levels, poor specific antibody responses, and exclusion of other causes of hypogammaglobulinemia.
