Defects in the complement system
ICD-10 D84.1 is a billable code used to indicate a diagnosis of defects in the complement system.
Defects in the complement system refer to a group of inherited or acquired disorders that affect the complement cascade, a crucial part of the immune system. The complement system consists of proteins that enhance the ability of antibodies and phagocytic cells to clear pathogens from an organism. Deficiencies or dysfunctions in these proteins can lead to increased susceptibility to infections, autoimmune diseases, and inflammatory conditions. Patients may present with recurrent infections, particularly with encapsulated organisms, and may also exhibit symptoms of autoimmune disorders due to the inability to regulate immune responses effectively. Diagnosis typically involves laboratory tests to assess complement levels and function, and management may include prophylactic antibiotics, immunoglobulin therapy, and treatment of associated autoimmune conditions. Understanding the nuances of these defects is essential for accurate coding and management of affected patients.
Detailed immunological assessments and laboratory results showing complement levels and function.
Patients presenting with recurrent infections or autoimmune symptoms requiring immunological evaluation.
Ensure comprehensive documentation of all clinical findings and laboratory results to support the diagnosis.
Complete blood counts and specific tests for complement system evaluation.
Patients with unexplained hematologic abnormalities or recurrent infections.
Document any associated hematologic conditions that may complicate the diagnosis.
Used to evaluate overall health and detect a variety of disorders, including hematologic conditions.
Document the reason for the CBC and any relevant clinical findings.
Immunologists and hematologists should ensure that the CBC is interpreted in the context of complement deficiencies.
Common symptoms include recurrent infections, particularly with encapsulated bacteria, and signs of autoimmune disorders such as joint pain, skin rashes, and fatigue.
