ICD-10 Logo
ICDxICD-10 Medical Coding
ICD-10 Logo
ICDxICD-10 Medical Coding
ICD 10 CodesDiagnoses
ICD 10 CodesDiagnoses
ICD-10 Logo
ICDxICD-10 Medical Coding

Comprehensive ICD-10-CM code reference with AI-powered search capabilities.

© 2025 ICD Code Compass. All rights reserved.

Browse

  • All Chapters
  • All Categories
  • Diagnoses

Tools

  • AI Code Search
ICD-10-CM codes are maintained by the CDC and CMS. This tool is for reference purposes only.
v1.0.0
ICD-10 Guide
ICD-10 CodesD84.82

D84.82

Billable

Immunodeficiency due to drugs and external causes

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/05/2025

Code Description

ICD-10 D84.82 is a billable code used to indicate a diagnosis of immunodeficiency due to drugs and external causes.

Key Diagnostic Point:

Immunodeficiency due to drugs and external causes refers to a condition where the immune system's ability to fight infections is compromised as a result of pharmacological agents or environmental factors. This can occur due to various medications, including immunosuppressants used in the treatment of autoimmune diseases, chemotherapy agents for cancer, or long-term corticosteroid therapy. The resulting immunodeficiency can lead to increased susceptibility to infections, prolonged illness, and complications such as opportunistic infections. Clinicians must carefully monitor patients on these medications for signs of infection and may need to implement prophylactic measures to prevent infections. The condition can also arise from external factors such as radiation exposure or certain toxins, which can damage the immune system. Accurate diagnosis and coding are essential for appropriate management and reimbursement, as well as for tracking the incidence of drug-induced immunodeficiency in clinical practice.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Variety of drugs and external causes that can lead to immunodeficiency.
  • Need for detailed patient history to determine causative agents.
  • Potential overlap with other immunodeficiency codes.
  • Documentation must specify the drug or external cause.

Audit Risk Factors

  • Inadequate documentation of the specific drug or external cause.
  • Failure to document the patient's clinical status and response to treatment.
  • Lack of follow-up notes indicating monitoring for infections.
  • Misclassification of the type of immunodeficiency.

Specialty Focus

Medical Specialties

Hematology/Oncology

Documentation Requirements

Detailed records of chemotherapy regimens, patient responses, and any infections encountered.

Common Clinical Scenarios

Patients undergoing chemotherapy who develop infections or complications due to immunosuppression.

Billing Considerations

Ensure that the specific chemotherapy agents are documented, as different agents have varying risks for immunodeficiency.

Rheumatology

Documentation Requirements

Thorough documentation of immunosuppressive therapy, including dosage and duration.

Common Clinical Scenarios

Patients with autoimmune diseases on long-term immunosuppressive therapy who present with infections.

Billing Considerations

Document the rationale for immunosuppressive therapy and any preventive measures taken.

Coding Guidelines

Inclusion Criteria

Use D84.82 When
  • According to ICD
  • 10 coding guidelines, D84
  • 82 should be used when the immunodeficiency is specifically attributed to drugs or external causes
  • Coders must ensure that the documentation clearly indicates the causative agent and the patient's clinical status

Exclusion Criteria

Do NOT use D84.82 When
  • Exclusion criteria include immunodeficiencies due to genetic factors or other underlying diseases

Related ICD-10 Codes

Related CPT Codes

96413CPT Code

Chemotherapy administration, intravenous, push technique, single or initial substance

Clinical Scenario

Used when administering chemotherapy that may lead to immunodeficiency.

Documentation Requirements

Document the specific chemotherapy agent and patient monitoring for side effects.

Specialty Considerations

Oncology specialists should ensure accurate coding of the chemotherapy regimen.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of immunodeficiencies, enabling better tracking of drug-induced cases and improving patient management strategies.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of immunodeficiencies, enabling better tracking of drug-induced cases and improving patient management strategies.

Reimbursement & Billing Impact

The transition to ICD-10 has allowed for more specific coding of immunodeficiencies, enabling better tracking of drug-induced cases and improving patient management strategies.

Resources

Clinical References

  • •
    ICD-10-CM Official Guidelines for Coding and Reporting

Coding & Billing References

  • •
    ICD-10-CM Official Guidelines for Coding and Reporting

Frequently Asked Questions

What types of drugs can cause immunodeficiency?

Various drugs, including chemotherapy agents, corticosteroids, and immunosuppressants, can lead to immunodeficiency by suppressing the immune system's function.