Mast cell activation syndrome and related disorders
ICD-10 D89.4 is a billable code used to indicate a diagnosis of mast cell activation syndrome and related disorders.
Mast cell activation syndrome (MCAS) is a condition characterized by inappropriate and excessive activation of mast cells, leading to a range of symptoms that can affect multiple organ systems. Mast cells are immune cells that play a crucial role in allergic responses and inflammation. In MCAS, mast cells release mediators such as histamine, cytokines, and other inflammatory substances without the typical triggers associated with allergic reactions. This can result in symptoms such as flushing, hives, abdominal pain, diarrhea, and anaphylaxis. The condition can be primary, secondary, or idiopathic, with primary MCAS often associated with clonal mast cell disorders. Diagnosis typically involves clinical evaluation, symptom assessment, and laboratory tests to measure mast cell mediators. Treatment focuses on symptom management and may include antihistamines, mast cell stabilizers, and avoidance of known triggers. Given the complexity of symptoms and the potential overlap with other conditions, accurate diagnosis and coding are essential for effective management and reimbursement.
Detailed patient history, symptom diary, and laboratory test results.
Patients presenting with recurrent anaphylaxis or unexplained allergic symptoms.
Ensure that all symptoms are documented, including triggers and response to treatments.
Complete blood counts, bone marrow biopsy results, and mast cell mediator levels.
Patients with hematologic disorders presenting with mast cell-related symptoms.
Document any hematologic abnormalities that may be related to mast cell activation.
Common symptoms include flushing, hives, abdominal pain, diarrhea, and anaphylaxis. Symptoms can vary widely among individuals.
