Secondary mast cell activation
ICD-10 D89.43 is a billable code used to indicate a diagnosis of secondary mast cell activation.
Secondary mast cell activation refers to the pathological activation of mast cells due to underlying conditions such as infections, autoimmune diseases, or malignancies. Mast cells are immune cells that play a crucial role in allergic responses and inflammation. In secondary mast cell activation, these cells become hyper-responsive, leading to the release of mediators such as histamine, cytokines, and other inflammatory substances. This can result in a range of symptoms including flushing, itching, abdominal pain, and anaphylaxis in severe cases. The condition is often associated with hematologic disorders, particularly those that involve dysregulation of the immune system, such as chronic myeloid leukemia or systemic mastocytosis. Accurate diagnosis typically requires a thorough clinical evaluation, including a detailed patient history, physical examination, and laboratory tests to assess mast cell mediators. Understanding the underlying cause of mast cell activation is essential for effective management and treatment, which may involve addressing the primary condition, using antihistamines, or other immunomodulatory therapies.
Detailed patient history, laboratory results indicating mast cell mediator levels, and documentation of any underlying hematologic disorders.
Patients with chronic myeloid leukemia presenting with symptoms of mast cell activation.
Ensure that the relationship between the hematologic condition and mast cell activation is clearly documented.
Comprehensive allergy history, symptom diary, and results from skin tests or serum tryptase levels.
Patients experiencing allergic reactions with a known underlying autoimmune disorder.
Documenting the specific triggers and responses to treatment is crucial for accurate coding.
Used to assess overall health and detect a variety of disorders, including mast cell activation.
Document the reason for the CBC and any relevant findings.
Hematology specialists should ensure that the CBC results are interpreted in the context of mast cell activation.
Common symptoms include flushing, itching, abdominal pain, and in severe cases, anaphylaxis. Symptoms can vary based on the underlying condition.
