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ICD-10 Guide
ICD-10 CodesE03.5

E03.5

Billable

Myxedema coma

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/05/2025

Code Description

ICD-10 E03.5 is a billable code used to indicate a diagnosis of myxedema coma.

Key Diagnostic Point:

Myxedema coma is a severe and life-threatening form of hypothyroidism characterized by a significant decrease in thyroid hormone levels, leading to a state of extreme metabolic slowdown. It typically occurs in individuals with long-standing untreated hypothyroidism, often precipitated by factors such as infection, cold exposure, trauma, or the use of certain medications. Clinically, patients may present with profound lethargy, hypothermia, bradycardia, hypotension, and altered mental status, which can progress to coma. The condition is marked by the accumulation of mucopolysaccharides in the skin and other tissues, leading to the characteristic myxedematous appearance. Diagnosis is confirmed through thyroid function tests, which typically show low levels of free thyroxine (T4) and elevated thyroid-stimulating hormone (TSH). Immediate treatment involves intravenous administration of thyroid hormone replacement, along with supportive care to address any precipitating factors. Due to its critical nature, myxedema coma requires prompt recognition and intervention to prevent morbidity and mortality.

Code Complexity Analysis

Complexity Rating: High

High Complexity

Complexity Factors

  • Requires understanding of thyroid function tests and their interpretation.
  • Differentiation from other forms of hypothyroidism and related conditions.
  • Need for comprehensive clinical documentation to support diagnosis.
  • Potential for co-existing conditions that may complicate coding.

Audit Risk Factors

  • Inadequate documentation of precipitating factors.
  • Failure to document thyroid function test results.
  • Misclassification of the severity of hypothyroidism.
  • Lack of clarity in the clinical presentation and treatment plan.

Specialty Focus

Medical Specialties

Endocrinology

Documentation Requirements

Thorough documentation of thyroid function tests, clinical symptoms, and treatment protocols.

Common Clinical Scenarios

Management of patients with chronic hypothyroidism presenting with acute decompensation.

Billing Considerations

Ensure clear documentation of the patient's history of thyroid disease and any recent changes in medication or health status.

Emergency Medicine

Documentation Requirements

Detailed notes on the patient's presentation, vital signs, and immediate interventions performed.

Common Clinical Scenarios

Patients presenting with altered mental status and hypothermia requiring rapid assessment and treatment.

Billing Considerations

Document all emergency interventions and the rationale for diagnosis to support coding.

Coding Guidelines

Inclusion Criteria

Use E03.5 When
  • Follow official ICD
  • CM coding guidelines, ensuring accurate documentation of the diagnosis, including any precipitating factors and associated conditions
  • Include relevant laboratory results to support the diagnosis

Exclusion Criteria

Do NOT use E03.5 When
No specific exclusions found.

Related ICD-10 Codes

Related CPT Codes

84443CPT Code

Thyroid stimulating hormone (TSH)

Clinical Scenario

Used to confirm diagnosis in patients suspected of myxedema coma.

Documentation Requirements

Document the rationale for testing and results.

Specialty Considerations

Endocrinologists should ensure comprehensive lab results are included in the patient's record.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of myxedema coma, improving the accuracy of diagnosis and treatment tracking. It emphasizes the need for detailed documentation to support the diagnosis.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of myxedema coma, improving the accuracy of diagnosis and treatment tracking. It emphasizes the need for detailed documentation to support the diagnosis.

Reimbursement & Billing Impact

The transition to ICD-10 has allowed for more specific coding of myxedema coma, improving the accuracy of diagnosis and treatment tracking. It emphasizes the need for detailed documentation to support the diagnosis.

Resources

Clinical References

  • •
    American Thyroid Association Guidelines

Coding & Billing References

  • •
    American Thyroid Association Guidelines

Frequently Asked Questions

What are the common symptoms of myxedema coma?

Common symptoms include severe lethargy, hypothermia, bradycardia, hypotension, and altered mental status. Patients may also exhibit dry skin and swelling.