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ICD-10 Guide
ICD-10 CodesE07.81

E07.81

Billable

Sick-euthyroid syndrome

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/05/2025

Code Description

ICD-10 E07.81 is a billable code used to indicate a diagnosis of sick-euthyroid syndrome.

Key Diagnostic Point:

Sick-euthyroid syndrome, also known as non-thyroidal illness syndrome, is a condition characterized by abnormal thyroid function tests in patients who are not suffering from intrinsic thyroid disease. This syndrome often occurs in the context of acute or chronic illness, such as infections, trauma, or systemic diseases. Patients typically present with low levels of thyroxine (T4) and triiodothyronine (T3), while thyroid-stimulating hormone (TSH) levels may remain normal or low. The underlying mechanism is thought to involve alterations in the hypothalamic-pituitary-thyroid axis due to the illness, leading to decreased conversion of T4 to T3 and increased peripheral metabolism of thyroid hormones. It is crucial to differentiate sick-euthyroid syndrome from true thyroid disorders, such as hypothyroidism or hyperthyroidism, as the management of these conditions differs significantly. Diagnosis is primarily based on clinical context and thyroid function tests, and treatment typically focuses on addressing the underlying illness rather than thyroid hormone replacement.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Differentiation from true thyroid disorders
  • Interpretation of thyroid function tests in the context of illness
  • Need for comprehensive patient history
  • Variability in clinical presentation

Audit Risk Factors

  • Inadequate documentation of underlying illness
  • Failure to differentiate from primary thyroid disorders
  • Misinterpretation of thyroid function tests
  • Lack of clinical correlation in documentation

Specialty Focus

Medical Specialties

Endocrinology

Documentation Requirements

Thorough documentation of thyroid function tests, patient history, and clinical context.

Common Clinical Scenarios

Patients with chronic illnesses presenting with abnormal thyroid function tests.

Billing Considerations

Endocrinologists must ensure that the diagnosis of sick-euthyroid syndrome is supported by comprehensive lab results and clinical findings.

Internal Medicine

Documentation Requirements

Detailed patient history and documentation of any acute or chronic illnesses affecting thyroid function.

Common Clinical Scenarios

Hospitalized patients with systemic illnesses showing altered thyroid hormone levels.

Billing Considerations

Internal medicine physicians should be aware of the implications of sick-euthyroid syndrome in the context of overall patient management.

Coding Guidelines

Inclusion Criteria

Use E07.81 When
  • According to ICD
  • 10 coding guidelines, E07
  • 81 should be used when the patient exhibits abnormal thyroid function tests without evidence of primary thyroid disease
  • It is essential to document the underlying condition contributing to the sick
  • euthyroid state

Exclusion Criteria

Do NOT use E07.81 When
  • Exclusion criteria include patients with known thyroid disorders that require separate coding

Related ICD-10 Codes

Related CPT Codes

84443CPT Code

Thyroid-stimulating hormone (TSH) test

Clinical Scenario

Used to evaluate thyroid function in patients suspected of having sick-euthyroid syndrome.

Documentation Requirements

Document the reason for the test and any relevant clinical findings.

Specialty Considerations

Endocrinologists should correlate TSH results with clinical context.

84436CPT Code

Thyroxine (T4) test

Clinical Scenario

Ordered to assess thyroid hormone levels in patients with systemic illness.

Documentation Requirements

Document the patient's clinical status and any underlying conditions.

Specialty Considerations

Internal medicine specialists should ensure comprehensive documentation.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of conditions like sick-euthyroid syndrome, improving the accuracy of diagnoses and treatment plans. This specificity aids in better understanding the impact of systemic illnesses on thyroid function.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of conditions like sick-euthyroid syndrome, improving the accuracy of diagnoses and treatment plans. This specificity aids in better understanding the impact of systemic illnesses on thyroid function.

Reimbursement & Billing Impact

reimbursement and to avoid audit issues.

Resources

Clinical References

  • •
    American Thyroid Association Guidelines

Coding & Billing References

  • •
    American Thyroid Association Guidelines

Frequently Asked Questions

What is sick-euthyroid syndrome?

Sick-euthyroid syndrome is a condition where thyroid function tests are abnormal due to non-thyroidal illness, without intrinsic thyroid disease.

How is sick-euthyroid syndrome diagnosed?

Diagnosis is based on abnormal thyroid function tests in the context of an underlying illness, requiring careful clinical evaluation.