Increased secretion of gastrin
ICD-10 E16.4 is a billable code used to indicate a diagnosis of increased secretion of gastrin.
Increased secretion of gastrin is a condition characterized by elevated levels of the hormone gastrin in the bloodstream, which is primarily produced by G cells in the gastric mucosa. This condition can lead to hypersecretion of gastric acid, resulting in various gastrointestinal disorders, including peptic ulcers and gastritis. Increased gastrin levels can be associated with several underlying conditions, including Zollinger-Ellison syndrome, chronic atrophic gastritis, and pancreatic islet disorders. In the context of glucose metabolism, elevated gastrin can influence insulin secretion and glucose homeostasis, potentially leading to hypoglycemia and hyperinsulinism. Patients may present with symptoms such as abdominal pain, diarrhea, and weight loss. Accurate diagnosis often requires a combination of clinical evaluation, laboratory tests to measure gastrin levels, and imaging studies to identify any underlying tumors or abnormalities in the pancreas or gastrointestinal tract.
Detailed documentation of symptoms, gastrin levels, and any imaging studies performed.
Patients presenting with recurrent peptic ulcers or unexplained abdominal pain.
Ensure that all relevant laboratory tests are documented, including baseline and stimulated gastrin levels.
Comprehensive endocrine evaluation, including insulin levels and glucose tolerance tests.
Patients with hypoglycemia and suspected hyperinsulinism.
Document the relationship between gastrin levels and insulin secretion to support the diagnosis.
Used to confirm increased gastrin levels in patients with suspected gastrin-secreting tumors.
Document the indication for the test and the results.
Gastroenterologists should ensure that the test is performed under appropriate clinical circumstances.
Common causes include gastrin-secreting tumors (gastrinomas), chronic atrophic gastritis, and certain pancreatic islet disorders. Each of these conditions can lead to elevated gastrin levels and associated gastrointestinal symptoms.
