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ICD-10 Guide
ICD-10 CodesE21.2

E21.2

Billable

Other hyperparathyroidism

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/05/2025

Code Description

ICD-10 E21.2 is a billable code used to indicate a diagnosis of other hyperparathyroidism.

Key Diagnostic Point:

Other hyperparathyroidism refers to conditions characterized by excessive secretion of parathyroid hormone (PTH) from the parathyroid glands, leading to elevated serum calcium levels. This condition can arise from various etiologies, including parathyroid adenomas, hyperplasia, or malignancies. Unlike primary hyperparathyroidism, which is often due to a solitary adenoma, other hyperparathyroidism may be secondary to chronic kidney disease or tertiary hyperparathyroidism, where the parathyroid glands become hyperplastic due to prolonged stimulation. Symptoms may include bone pain, kidney stones, fatigue, and gastrointestinal disturbances. Diagnosis typically involves serum calcium and PTH level measurements, alongside imaging studies to assess for parathyroid abnormalities. Management may involve surgical intervention, particularly in cases of adenomas, or medical management in secondary cases, focusing on the underlying cause of the hyperparathyroidism.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Differentiating between primary, secondary, and tertiary hyperparathyroidism.
  • Understanding the underlying causes and associated conditions.
  • Interpreting laboratory results accurately for diagnosis.
  • Navigating the documentation requirements for surgical versus medical management.

Audit Risk Factors

  • Inadequate documentation of the underlying cause of hyperparathyroidism.
  • Failure to document laboratory results that support the diagnosis.
  • Incorrect coding of related conditions or complications.
  • Lack of clarity in distinguishing between primary and secondary hyperparathyroidism.

Specialty Focus

Medical Specialties

Endocrinology

Documentation Requirements

Thorough documentation of hormone levels, imaging studies, and treatment plans.

Common Clinical Scenarios

Patients presenting with hypercalcemia, bone pain, or kidney stones.

Billing Considerations

Endocrinologists must ensure that all relevant lab results and imaging studies are included in the documentation to support the diagnosis.

Nephrology

Documentation Requirements

Detailed records of kidney function tests and management of secondary causes.

Common Clinical Scenarios

Patients with chronic kidney disease presenting with elevated PTH levels.

Billing Considerations

Nephrologists should document the relationship between kidney function and parathyroid hormone levels to justify the diagnosis.

Coding Guidelines

Inclusion Criteria

Use E21.2 When
  • According to ICD
  • 10 coding guidelines, E21
  • 2 should be used when hyperparathyroidism is not classified as primary or secondary
  • Coders must ensure that the underlying cause is documented and that any related conditions are coded appropriately

Exclusion Criteria

Do NOT use E21.2 When
No specific exclusions found.

Related ICD-10 Codes

Related CPT Codes

60500CPT Code

Parathyroidectomy

Clinical Scenario

Used in cases of parathyroid adenoma leading to hyperparathyroidism.

Documentation Requirements

Operative reports must detail the procedure and findings.

Specialty Considerations

Endocrinologists must ensure that the surgical necessity is well-documented.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of hyperparathyroidism, enabling better tracking of the condition and its causes. This specificity aids in research and treatment planning.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of hyperparathyroidism, enabling better tracking of the condition and its causes. This specificity aids in research and treatment planning.

Reimbursement & Billing Impact

reimbursement.

Resources

Clinical References

  • •
    ICD-10-CM Official Guidelines for Coding and Reporting

Coding & Billing References

  • •
    ICD-10-CM Official Guidelines for Coding and Reporting

Frequently Asked Questions

What is the difference between primary and other hyperparathyroidism?

Primary hyperparathyroidism is typically caused by a solitary adenoma, while other hyperparathyroidism can result from various conditions, including chronic kidney disease or parathyroid hyperplasia.