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ICD-10 Guide
ICD-10 CodesE21.4

E21.4

Billable

Other specified disorders of parathyroid gland

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/05/2025

Code Description

ICD-10 E21.4 is a billable code used to indicate a diagnosis of other specified disorders of parathyroid gland.

Key Diagnostic Point:

The parathyroid glands are small endocrine glands located behind the thyroid gland that play a crucial role in regulating calcium levels in the blood through the secretion of parathyroid hormone (PTH). Disorders of the parathyroid gland can lead to abnormal calcium metabolism, resulting in conditions such as hyperparathyroidism or hypoparathyroidism. E21.4 encompasses a variety of less common parathyroid disorders that do not fit neatly into the more defined categories of primary or secondary hyperparathyroidism. These may include conditions such as parathyroid adenomas, parathyroid carcinoma, or genetic syndromes affecting parathyroid function. Clinically, patients may present with symptoms related to calcium imbalance, including bone pain, kidney stones, fatigue, and neuromuscular irritability. Diagnosis typically involves serum calcium and PTH level measurements, imaging studies, and sometimes biopsy. Treatment options vary based on the specific disorder but may include surgical intervention, medication to manage calcium levels, or monitoring in asymptomatic cases. Accurate coding of these disorders is essential for appropriate treatment and reimbursement.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Variety of underlying conditions that can lead to parathyroid dysfunction.
  • Need for precise documentation of laboratory results and imaging studies.
  • Differentiation from other endocrine disorders, such as those involving the pituitary or adrenal glands.
  • Potential for overlapping symptoms with other conditions, complicating diagnosis.

Audit Risk Factors

  • Inadequate documentation of laboratory results.
  • Failure to specify the type of parathyroid disorder.
  • Misclassification of parathyroid disorders as thyroid disorders.
  • Inconsistent coding practices across different providers.

Specialty Focus

Medical Specialties

Endocrinology

Documentation Requirements

Detailed clinical notes including lab results, imaging studies, and treatment plans.

Common Clinical Scenarios

Patients presenting with hypercalcemia, bone pain, or kidney stones.

Billing Considerations

Endocrinologists must ensure that all relevant endocrine disorders are considered and documented.

Surgery

Documentation Requirements

Operative reports detailing the surgical approach and findings during parathyroid surgery.

Common Clinical Scenarios

Patients undergoing parathyroidectomy for adenomas or carcinoma.

Billing Considerations

Surgeons should document the rationale for surgery and any intraoperative findings.

Coding Guidelines

Inclusion Criteria

Use E21.4 When
  • According to ICD
  • 10 coding guidelines, E21
  • 4 should be used when the specific disorder of the parathyroid gland is not classified elsewhere
  • Coders must ensure that the documentation supports the diagnosis and that any related conditions are also coded appropriately

Exclusion Criteria

Do NOT use E21.4 When
No specific exclusions found.

Related ICD-10 Codes

Related CPT Codes

60500CPT Code

Parathyroidectomy

Clinical Scenario

Used when a patient undergoes surgery for a parathyroid adenoma.

Documentation Requirements

Operative report detailing the procedure and findings.

Specialty Considerations

Endocrinologists and surgeons must coordinate documentation to ensure accurate coding.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of parathyroid disorders, enabling better tracking of these conditions and their management. E21.4 provides a means to capture less common disorders that may have been previously overlooked in ICD-9.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of parathyroid disorders, enabling better tracking of these conditions and their management. E21.4 provides a means to capture less common disorders that may have been previously overlooked in ICD-9.

Reimbursement & Billing Impact

reimbursement.

Resources

Clinical References

  • •
    ICD-10-CM Official Guidelines for Coding and Reporting

Coding & Billing References

  • •
    ICD-10-CM Official Guidelines for Coding and Reporting

Frequently Asked Questions

What types of conditions are included under E21.4?

E21.4 includes various unspecified disorders of the parathyroid gland, such as rare genetic syndromes, parathyroid adenomas, and other conditions that do not fit into the more defined categories of hyperparathyroidism.

How can I ensure accurate coding for parathyroid disorders?

Accurate coding requires thorough documentation of the patient's clinical presentation, laboratory results, and any imaging studies. Always verify that the specific disorder is clearly identified in the medical record.