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ICD-10 Guide
ICD-10 CodesChapter 4: Endocrine, nutritional and metabolic diseasesE22

E22

Billable

Hyperfunction of pituitary gland

Chapter 4:Endocrine, nutritional and metabolic diseases

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/05/2025

Code Description

ICD-10 E22 is a billable code used to indicate a diagnosis of hyperfunction of pituitary gland.

Key Diagnostic Point:

Hyperfunction of the pituitary gland refers to an overproduction of hormones due to excessive activity of the pituitary gland, which is a small gland located at the base of the brain. This condition can lead to various endocrine disorders, including acromegaly, Cushing's disease, and hyperprolactinemia, depending on which hormone is overproduced. The pituitary gland regulates several critical bodily functions by releasing hormones that control other endocrine glands, such as the adrenal glands and thyroid. Symptoms may vary widely but often include abnormal growth patterns, changes in metabolism, and reproductive issues. Diagnosis typically involves hormonal assays, imaging studies like MRI, and clinical evaluations. Treatment options may include surgical intervention, medication to inhibit hormone production, or radiation therapy. Accurate coding of hyperfunction of the pituitary gland is essential for proper management and reimbursement, as it can significantly impact patient care and treatment pathways.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Variety of symptoms associated with different hormone overproductions
  • Need for precise documentation of hormone levels and clinical findings
  • Potential overlap with other endocrine disorders
  • Variability in treatment approaches based on specific hormone excess

Audit Risk Factors

  • Inadequate documentation of hormone levels
  • Failure to specify the type of hyperfunction (e.g., acromegaly, Cushing's)
  • Lack of imaging study results in the medical record
  • Misclassification of related endocrine disorders

Specialty Focus

Medical Specialties

Endocrinology

Documentation Requirements

Detailed lab results, imaging studies, and clinical evaluations must be documented.

Common Clinical Scenarios

Patients presenting with symptoms of hormone excess, such as abnormal growth or menstrual irregularities.

Billing Considerations

Endocrinologists must ensure that all relevant hormone assays are documented to support the diagnosis.

Neurosurgery

Documentation Requirements

Surgical reports, pre-operative evaluations, and post-operative follow-ups are critical.

Common Clinical Scenarios

Patients undergoing surgery for pituitary tumors causing hyperfunction.

Billing Considerations

Documentation must clearly outline the surgical approach and any complications related to the pituitary gland.

Coding Guidelines

Inclusion Criteria

Use E22 When
  • Follow official ICD
  • 10 coding guidelines, ensuring accurate documentation of the specific type of hyperfunction and any related conditions
  • Include relevant lab results and imaging studies to support the diagnosis

Exclusion Criteria

Do NOT use E22 When
No specific exclusions found.

Related CPT Codes

88305CPT Code

Pathology examination of pituitary tissue

Clinical Scenario

Used when a pituitary tumor is excised and sent for pathology.

Documentation Requirements

Pathology report must be included in the medical record.

Specialty Considerations

Endocrinologists and neurosurgeons should ensure that the pathology findings correlate with the diagnosis.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of pituitary disorders, improving the accuracy of diagnoses and treatment plans. This specificity aids in better tracking of patient outcomes and resource allocation.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of pituitary disorders, improving the accuracy of diagnoses and treatment plans. This specificity aids in better tracking of patient outcomes and resource allocation.

Reimbursement & Billing Impact

The transition to ICD-10 has allowed for more specific coding of pituitary disorders, improving the accuracy of diagnoses and treatment plans. This specificity aids in better tracking of patient outcomes and resource allocation.

Resources

Clinical References

  • •
    ICD-10-CM Official Guidelines for Coding and Reporting

Coding & Billing References

  • •
    ICD-10-CM Official Guidelines for Coding and Reporting

Frequently Asked Questions

What are the common symptoms of hyperfunction of the pituitary gland?

Common symptoms include abnormal growth patterns, changes in menstrual cycles, weight gain, hypertension, and signs of hormone excess such as galactorrhea or acromegaly.

How is hyperfunction of the pituitary gland diagnosed?

Diagnosis typically involves clinical evaluation, hormone level testing, and imaging studies such as MRI to identify any tumors or abnormalities in the pituitary gland.