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v1.0.0
ICD-10 Guide
ICD-10 CodesE22.1

E22.1

Billable

Hyperprolactinemia

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/05/2025

Code Description

ICD-10 E22.1 is a billable code used to indicate a diagnosis of hyperprolactinemia.

Key Diagnostic Point:

Hyperprolactinemia is a condition characterized by elevated levels of prolactin, a hormone produced by the pituitary gland. This condition can result from various factors, including pituitary tumors (prolactinomas), hypothyroidism, and certain medications. Prolactin plays a crucial role in lactation and reproductive health, and its dysregulation can lead to symptoms such as galactorrhea (unexplained milk production), amenorrhea (absence of menstruation), and infertility. In men, hyperprolactinemia can cause erectile dysfunction and decreased libido. The diagnosis is typically confirmed through serum prolactin level testing, and management may involve treating the underlying cause, such as medication adjustments or surgical intervention for tumors. Understanding the endocrine pathways and the interplay between the pituitary, hypothalamus, and other glands is essential for effective diagnosis and treatment.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Differentiating between primary and secondary causes of hyperprolactinemia.
  • Understanding the implications of various medications that can elevate prolactin levels.
  • Recognizing associated endocrine disorders that may complicate the diagnosis.
  • Navigating the documentation requirements for hormone level testing and imaging studies.

Audit Risk Factors

  • Inadequate documentation of symptoms leading to the diagnosis.
  • Failure to document the underlying cause of hyperprolactinemia.
  • Lack of follow-up documentation for treatment efficacy.
  • Misclassification of the condition as primary when it is secondary.

Specialty Focus

Medical Specialties

Endocrinology

Documentation Requirements

Detailed hormone level tests, imaging studies, and treatment plans.

Common Clinical Scenarios

Patients presenting with infertility, menstrual irregularities, or galactorrhea.

Billing Considerations

Ensure comprehensive documentation of all endocrine evaluations and treatments.

Gynecology

Documentation Requirements

Menstrual history, pregnancy status, and any related reproductive health issues.

Common Clinical Scenarios

Women presenting with amenorrhea or galactorrhea.

Billing Considerations

Document any hormonal treatments or contraceptive use that may affect prolactin levels.

Coding Guidelines

Inclusion Criteria

Use E22.1 When
  • According to ICD
  • 10 guidelines, E22
  • 1 should be used when hyperprolactinemia is confirmed by laboratory tests
  • It is important to document the underlying cause if known, as this may affect treatment and management

Exclusion Criteria

Do NOT use E22.1 When
No specific exclusions found.

Related ICD-10 Codes

Related CPT Codes

84146CPT Code

Prolactin test

Clinical Scenario

Used to confirm diagnosis of hyperprolactinemia.

Documentation Requirements

Document the reason for testing and any relevant clinical history.

Specialty Considerations

Endocrinologists should ensure comprehensive lab results are included.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of hyperprolactinemia, improving the accuracy of data collection and reimbursement processes. It emphasizes the importance of documenting the underlying causes and associated symptoms.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of hyperprolactinemia, improving the accuracy of data collection and reimbursement processes. It emphasizes the importance of documenting the underlying causes and associated symptoms.

Reimbursement & Billing Impact

reimbursement processes. It emphasizes the importance of documenting the underlying causes and associated symptoms.

Resources

Clinical References

  • •
    American Association of Clinical Endocrinologists

Coding & Billing References

  • •
    American Association of Clinical Endocrinologists

Frequently Asked Questions

What are the common causes of hyperprolactinemia?

Common causes include prolactinomas, hypothyroidism, certain medications (like antipsychotics), and stress. Each cause may require different management strategies.