Drug-induced Cushing's syndrome
ICD-10 E24.2 is a billable code used to indicate a diagnosis of drug-induced cushing's syndrome.
Drug-induced Cushing's syndrome is a condition characterized by excessive levels of cortisol in the body due to the administration of certain medications. This syndrome mimics the symptoms of endogenous Cushing's syndrome, which can include obesity, hypertension, diabetes, and skin changes. The condition arises when glucocorticoids, often prescribed for inflammatory conditions, autoimmune diseases, or as part of cancer treatment, lead to an overproduction of cortisol. The adrenal glands, which produce cortisol, may become suppressed due to the external source of glucocorticoids, leading to a feedback loop that exacerbates hormone imbalances. Clinicians must carefully monitor patients on long-term glucocorticoid therapy for signs of Cushing's syndrome, as early detection can prevent significant morbidity. Diagnosis typically involves clinical evaluation, biochemical tests to measure cortisol levels, and imaging studies to assess adrenal function. Management may require tapering off the offending drug, switching to alternative therapies, or addressing the symptoms of Cushing's syndrome directly.
Thorough documentation of hormone levels, medication history, and clinical symptoms.
Patients presenting with symptoms of Cushing's syndrome while on glucocorticoid therapy.
Endocrinologists must differentiate between drug-induced and primary causes of Cushing's syndrome.
Detailed records of medication prescriptions, dosages, and duration of therapy.
Reviewing patient medication regimens for potential glucocorticoid use.
Pharmacists should be aware of the potential for drug-induced Cushing's when counseling patients.
Used to confirm elevated cortisol levels in suspected cases of drug-induced Cushing's syndrome.
Document the reason for testing and the patient's medication history.
Endocrinologists should ensure comprehensive testing protocols are followed.
Common medications include glucocorticoids such as prednisone, dexamethasone, and hydrocortisone, often used for inflammatory or autoimmune conditions.
