Ectopic ACTH syndrome
ICD-10 E24.3 is a billable code used to indicate a diagnosis of ectopic acth syndrome.
Ectopic ACTH syndrome is a rare endocrine disorder characterized by the production of adrenocorticotropic hormone (ACTH) from non-pituitary tumors, leading to excessive cortisol production by the adrenal glands. This condition is often associated with malignancies, particularly small cell lung cancer, but can also arise from other neoplasms such as carcinoid tumors and pancreatic tumors. The ectopic secretion of ACTH results in Cushing's syndrome, which manifests with symptoms such as obesity, hypertension, diabetes mellitus, and skin changes. Diagnosis typically involves biochemical tests to measure cortisol and ACTH levels, imaging studies to identify the source of ectopic ACTH production, and possibly a biopsy of the tumor. Management may include surgical resection of the tumor, medical therapy to control cortisol levels, and treatment of the underlying malignancy. Understanding the interplay between the adrenal glands, pituitary gland, and the tumors responsible for ectopic ACTH production is crucial for effective diagnosis and treatment.
Detailed hormone level assessments, imaging studies, and treatment plans.
Patients presenting with symptoms of Cushing's syndrome and abnormal ACTH levels.
Ensure accurate documentation of all endocrine evaluations and multidisciplinary consultations.
Pathology reports, imaging results, and treatment protocols for the underlying malignancy.
Patients with known malignancies presenting with signs of hypercortisolism.
Document the relationship between the tumor and ectopic ACTH production clearly.
Used to confirm hypercortisolism in suspected cases of ectopic ACTH syndrome.
Document the reason for the test and the clinical findings leading to it.
Endocrinologists should ensure comprehensive hormone evaluations are included.
Ectopic ACTH syndrome is a condition where non-pituitary tumors produce ACTH, leading to excess cortisol production and symptoms of Cushing's syndrome.
Diagnosis involves measuring serum cortisol and ACTH levels, imaging studies to locate the tumor, and possibly a biopsy.
Common causes include small cell lung cancer, carcinoid tumors, and pancreatic tumors.
