Adrenogenital disorders
Chapter 4:Endocrine, nutritional and metabolic diseases
ICD-10 E25 is a billable code used to indicate a diagnosis of adrenogenital disorders.
Adrenogenital disorders encompass a group of conditions resulting from abnormal hormone production by the adrenal glands, particularly androgens. These disorders are primarily caused by congenital adrenal hyperplasia (CAH), which is a genetic disorder affecting adrenal steroidogenesis. The most common form of CAH is due to 21-hydroxylase deficiency, leading to an accumulation of steroid precursors and a deficiency in cortisol and aldosterone. This hormonal imbalance can result in virilization in females, early onset of puberty in males, and adrenal crisis due to insufficient cortisol. Symptoms may include ambiguous genitalia in newborns, hirsutism, menstrual irregularities, and infertility. Diagnosis typically involves biochemical tests to measure hormone levels, genetic testing, and imaging studies to assess adrenal gland structure. Management often includes glucocorticoid replacement therapy to normalize hormone levels and prevent adrenal crisis. Regular monitoring is essential to adjust treatment and manage potential complications.
Detailed hormone level assessments, genetic testing results, and treatment plans.
Diagnosis and management of congenital adrenal hyperplasia, monitoring of hormone replacement therapy.
Ensure documentation reflects the complexity of hormone imbalances and the need for multidisciplinary care.
Growth and development assessments, family history of endocrine disorders.
Evaluation of ambiguous genitalia in newborns, early signs of puberty in children.
Focus on developmental milestones and psychosocial impacts of the disorder.
Used to evaluate androgen levels in suspected adrenogenital disorders.
Document the clinical rationale for testing and results.
Endocrinologists should ensure comprehensive hormone panels are ordered.
Common symptoms include ambiguous genitalia in newborns, hirsutism, menstrual irregularities, and signs of adrenal crisis such as fatigue, weakness, and low blood pressure.
