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v1.0.0
ICD-10 Guide
ICD-10 CodesE28.0

E28.0

Billable

Estrogen excess

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/05/2025

Code Description

ICD-10 E28.0 is a billable code used to indicate a diagnosis of estrogen excess.

Key Diagnostic Point:

Estrogen excess, also known as estrogen dominance, refers to a condition characterized by an imbalance in the levels of estrogen relative to other hormones, particularly progesterone. This condition can arise from various factors including hormonal disorders, certain medications, obesity, and environmental factors. Estrogen excess can lead to a range of symptoms and health issues, including menstrual irregularities, weight gain, mood swings, and increased risk of certain cancers, particularly breast and endometrial cancer. In the context of endocrine disorders, estrogen excess may be associated with dysfunctions of the pituitary gland, which regulates hormone production, and the adrenal glands, which produce steroid hormones. Additionally, parathyroid disorders can indirectly influence estrogen metabolism and balance. Accurate diagnosis often requires a comprehensive evaluation of hormone levels, including estrogen, progesterone, and other related hormones, alongside clinical assessments of symptoms. Treatment may involve lifestyle modifications, hormone therapy, or addressing underlying conditions contributing to the hormonal imbalance.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Variability in symptoms and presentations among patients
  • Need for comprehensive hormone level testing
  • Potential overlap with other endocrine disorders
  • Documentation of clinical findings and treatment plans

Audit Risk Factors

  • Inadequate documentation of hormone levels
  • Failure to document clinical symptoms
  • Misclassification of estrogen excess as other conditions
  • Lack of follow-up documentation on treatment efficacy

Specialty Focus

Medical Specialties

Endocrinology

Documentation Requirements

Detailed hormone level tests, clinical symptoms, and treatment plans.

Common Clinical Scenarios

Patients presenting with menstrual irregularities, weight gain, or mood changes.

Billing Considerations

Ensure comprehensive documentation of all hormone levels and related symptoms.

Gynecology

Documentation Requirements

Menstrual history, physical examination findings, and treatment response.

Common Clinical Scenarios

Women experiencing heavy menstrual bleeding or symptoms of PMS.

Billing Considerations

Document any gynecological examinations and findings related to estrogen excess.

Coding Guidelines

Inclusion Criteria

Use E28.0 When
  • Follow official ICD
  • 10 coding guidelines, ensuring accurate documentation of the condition's clinical manifestations and any related endocrine disorders
  • Include relevant lab results and treatment plans

Exclusion Criteria

Do NOT use E28.0 When
No specific exclusions found.

Related ICD-10 Codes

Related CPT Codes

83001CPT Code

Estradiol test

Clinical Scenario

Used to evaluate estrogen levels in patients suspected of having estrogen excess.

Documentation Requirements

Document the reason for testing and the patient's symptoms.

Specialty Considerations

Endocrinologists should ensure comprehensive hormone panels are ordered.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of estrogen-related conditions, improving the accuracy of diagnoses and treatment tracking. E28.0 provides a clear designation for estrogen excess, facilitating better patient management.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of estrogen-related conditions, improving the accuracy of diagnoses and treatment tracking. E28.0 provides a clear designation for estrogen excess, facilitating better patient management.

Reimbursement & Billing Impact

The transition to ICD-10 has allowed for more specific coding of estrogen-related conditions, improving the accuracy of diagnoses and treatment tracking. E28.0 provides a clear designation for estrogen excess, facilitating better patient management.

Resources

Clinical References

  • •
    ICD-10-CM Official Guidelines for Coding and Reporting

Coding & Billing References

  • •
    ICD-10-CM Official Guidelines for Coding and Reporting

Frequently Asked Questions

What are the common symptoms of estrogen excess?

Common symptoms include heavy menstrual bleeding, mood swings, weight gain, breast tenderness, and increased risk of endometrial hyperplasia.

How is estrogen excess diagnosed?

Diagnosis typically involves hormone level testing, clinical evaluations of symptoms, and consideration of any underlying endocrine disorders.