Autoimmune polyglandular failure
ICD-10 E31.0 is a billable code used to indicate a diagnosis of autoimmune polyglandular failure.
Autoimmune polyglandular failure (APF) is a complex endocrine disorder characterized by the simultaneous or sequential failure of multiple endocrine glands due to autoimmune destruction. This condition often presents in childhood or adolescence, leading to significant hormonal imbalances that can affect growth and development. Commonly involved glands include the thyroid, adrenal glands, and pancreas, resulting in conditions such as Addison's disease, hypothyroidism, and type 1 diabetes. The thymus gland, which plays a crucial role in immune function, may also be affected, leading to increased susceptibility to infections and other autoimmune disorders. Patients may exhibit growth abnormalities due to deficiencies in growth hormone or other hormones, which can manifest as delayed puberty or stunted growth. Diagnosis typically involves a combination of clinical evaluation, laboratory tests to assess hormone levels, and imaging studies to evaluate gland structure and function. Management often requires hormone replacement therapy and careful monitoring of endocrine function to prevent complications.
Thorough documentation of hormone levels, clinical symptoms, and treatment plans.
Patients presenting with fatigue, weight changes, or growth abnormalities.
Ensure all affected glands are documented to support the diagnosis.
Detailed growth charts and developmental assessments.
Children with delayed puberty or unexplained growth failure.
Monitor for signs of other autoimmune conditions that may co-occur.
Used to evaluate thyroid function in patients with suspected APF.
Document the reason for testing and any relevant clinical findings.
Endocrinologists should ensure comprehensive hormone panels are ordered.
Common symptoms include fatigue, weight changes, growth abnormalities, and signs of hormonal deficiencies such as delayed puberty or adrenal crisis.
