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ICD-10 Guide
ICD-10 CodesE34.2

E34.2

Billable

Ectopic hormone secretion, not elsewhere classified

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/05/2025

Code Description

ICD-10 E34.2 is a billable code used to indicate a diagnosis of ectopic hormone secretion, not elsewhere classified.

Key Diagnostic Point:

Ectopic hormone secretion refers to the production of hormones by non-endocrine tissues, which can lead to various clinical manifestations. This condition is often associated with tumors, particularly neuroendocrine tumors, that secrete hormones inappropriately. In the context of puberty disorders, ectopic hormone secretion can disrupt normal growth and sexual maturation processes. For instance, excessive secretion of hormones such as adrenocorticotropic hormone (ACTH) can lead to precocious puberty or growth abnormalities. Polyglandular dysfunction may occur when multiple endocrine glands are affected, leading to a complex interplay of hormonal imbalances. Thymus disorders, while less common, can also contribute to ectopic hormone secretion, particularly in the context of autoimmune conditions. Growth abnormalities may manifest as either excessive growth or stunted growth, depending on the nature of the ectopic hormone being secreted. Accurate diagnosis and management require a multidisciplinary approach, including endocrinology, oncology, and sometimes surgery, to address the underlying cause of the ectopic hormone production.

Code Complexity Analysis

Complexity Rating: High

High Complexity

Complexity Factors

  • Variety of potential underlying causes (e.g., tumors, autoimmune disorders)
  • Overlap with other endocrine disorders
  • Need for comprehensive diagnostic workup
  • Potential for multiple hormone imbalances

Audit Risk Factors

  • Inadequate documentation of the underlying cause
  • Failure to specify the type of ectopic hormone involved
  • Misclassification of related endocrine disorders
  • Lack of clarity in clinical notes regarding symptoms

Specialty Focus

Medical Specialties

Endocrinology

Documentation Requirements

Detailed hormonal assays, imaging studies, and clinical symptoms must be documented.

Common Clinical Scenarios

Patients presenting with abnormal growth patterns, precocious puberty, or unexplained hormonal imbalances.

Billing Considerations

Endocrinologists should ensure that all relevant hormone levels are tested and documented to support the diagnosis.

Oncology

Documentation Requirements

Pathology reports, imaging studies, and treatment plans for tumors causing ectopic hormone secretion.

Common Clinical Scenarios

Patients with neuroendocrine tumors presenting with symptoms of hormone excess.

Billing Considerations

Oncologists must document the tumor type and its hormonal effects clearly to support coding.

Coding Guidelines

Inclusion Criteria

Use E34.2 When
  • According to ICD
  • 10 guidelines, E34
  • 2 should be used when ectopic hormone secretion is confirmed but does not fit into more specific categories
  • Coders must ensure that the documentation supports the diagnosis and that other potential causes are ruled out

Exclusion Criteria

Do NOT use E34.2 When
No specific exclusions found.

Related ICD-10 Codes

Related CPT Codes

83001CPT Code

Growth hormone (GH) test

Clinical Scenario

Used to evaluate suspected growth hormone deficiency or excess.

Documentation Requirements

Document the reason for testing and any relevant clinical findings.

Specialty Considerations

Endocrinologists should correlate test results with clinical symptoms.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of ectopic hormone secretion, improving the ability to capture the complexity of these cases. This specificity aids in better tracking of patient outcomes and resource allocation.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of ectopic hormone secretion, improving the ability to capture the complexity of these cases. This specificity aids in better tracking of patient outcomes and resource allocation.

Reimbursement & Billing Impact

reimbursement.

Resources

Clinical References

  • •
    ICD-10-CM Official Guidelines for Coding and Reporting

Coding & Billing References

  • •
    ICD-10-CM Official Guidelines for Coding and Reporting

Frequently Asked Questions

What is ectopic hormone secretion?

Ectopic hormone secretion occurs when hormones are produced by non-endocrine tissues, often due to tumors, leading to various clinical symptoms and hormonal imbalances.

How is ectopic hormone secretion diagnosed?

Diagnosis typically involves hormonal assays, imaging studies, and clinical evaluation to identify the source of hormone production.

What are the common symptoms of ectopic hormone secretion?

Symptoms can vary widely but may include abnormal growth patterns, metabolic disturbances, and signs of hormonal excess or deficiency.

Can ectopic hormone secretion be treated?

Treatment depends on the underlying cause and may include surgical intervention, medication to manage hormone levels, or treatment of the underlying tumor.