ICD-10 Logo
ICDxICD-10 Medical Coding
ICD-10 Logo
ICDxICD-10 Medical Coding
ICD 10 CodesDiagnoses
ICD 10 CodesDiagnoses
ICD-10 Logo
ICDxICD-10 Medical Coding

Comprehensive ICD-10-CM code reference with AI-powered search capabilities.

© 2025 ICD Code Compass. All rights reserved.

Browse

  • All Chapters
  • All Categories
  • Diagnoses

Tools

  • AI Code Search
ICD-10-CM codes are maintained by the CDC and CMS. This tool is for reference purposes only.
v1.0.0
ICD-10 Guide
ICD-10 CodesE53.1

E53.1

Billable

Pyridoxine deficiency

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/05/2025

Code Description

ICD-10 E53.1 is a billable code used to indicate a diagnosis of pyridoxine deficiency.

Key Diagnostic Point:

Pyridoxine deficiency, also known as vitamin B6 deficiency, occurs when there is an insufficient amount of vitamin B6 in the body. This vitamin is crucial for numerous physiological functions, including amino acid metabolism, neurotransmitter synthesis, and the production of hemoglobin. Symptoms of pyridoxine deficiency can include peripheral neuropathy, anemia, depression, confusion, and weakened immune function. The deficiency can arise from inadequate dietary intake, malabsorption syndromes, certain medications, or chronic conditions such as kidney disease. Diagnosis typically involves clinical evaluation and may be supported by laboratory tests measuring plasma pyridoxal phosphate levels. Treatment primarily focuses on dietary modification to include vitamin B6-rich foods such as poultry, fish, potatoes, chickpeas, bananas, and fortified cereals, along with supplementation when necessary. It is essential for healthcare providers to recognize the signs of deficiency early to prevent complications and ensure proper management.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Variability in symptoms and presentation among patients
  • Potential overlap with other vitamin deficiencies
  • Need for specific dietary history and laboratory results for accurate diagnosis
  • Documentation of underlying causes or contributing factors

Audit Risk Factors

  • Inadequate documentation of dietary intake
  • Failure to document associated symptoms or conditions
  • Lack of laboratory test results supporting the diagnosis
  • Misclassification of deficiency type

Specialty Focus

Medical Specialties

Nutrition

Documentation Requirements

Detailed dietary history and assessment of nutritional status.

Common Clinical Scenarios

Patients presenting with unexplained fatigue, neuropathy, or anemia.

Billing Considerations

Ensure thorough documentation of dietary sources of vitamin B6 and any supplementation.

Neurology

Documentation Requirements

Neurological assessments and symptom descriptions.

Common Clinical Scenarios

Patients with neurological symptoms such as peripheral neuropathy or cognitive changes.

Billing Considerations

Document any differential diagnoses considered and the rationale for testing.

Coding Guidelines

Inclusion Criteria

Use E53.1 When
  • According to the ICD
  • 10 coding guidelines, E53
  • 1 should be used when there is a confirmed diagnosis of pyridoxine deficiency
  • It is important to document the clinical findings, dietary history, and any laboratory results that support the diagnosis

Exclusion Criteria

Do NOT use E53.1 When
  • Exclusion criteria include other vitamin deficiencies that may present similarly

Related ICD-10 Codes

Related CPT Codes

84520CPT Code

Vitamin B6 level test

Clinical Scenario

When a patient presents with symptoms suggestive of deficiency.

Documentation Requirements

Document the clinical rationale for testing and any relevant symptoms.

Specialty Considerations

Ensure that the specialty performing the test is noted for accurate billing.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of vitamin deficiencies, including pyridoxine deficiency. This specificity aids in better tracking of nutritional deficiencies and their management in clinical practice.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of vitamin deficiencies, including pyridoxine deficiency. This specificity aids in better tracking of nutritional deficiencies and their management in clinical practice.

Reimbursement & Billing Impact

The transition to ICD-10 has allowed for more specific coding of vitamin deficiencies, including pyridoxine deficiency. This specificity aids in better tracking of nutritional deficiencies and their management in clinical practice.

Resources

Clinical References

  • •
    National Institutes of Health - Vitamin B6

Coding & Billing References

  • •
    National Institutes of Health - Vitamin B6

Frequently Asked Questions

What are the common symptoms of pyridoxine deficiency?

Common symptoms include peripheral neuropathy, anemia, depression, confusion, and weakened immune function.

How is pyridoxine deficiency diagnosed?

Diagnosis is typically made through clinical evaluation, dietary history, and laboratory tests measuring plasma pyridoxal phosphate levels.

What foods are rich in vitamin B6?

Foods rich in vitamin B6 include poultry, fish, potatoes, chickpeas, bananas, and fortified cereals.

Can pyridoxine deficiency be treated?

Yes, treatment involves dietary modifications to include vitamin B6-rich foods and supplementation when necessary.