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ICD-10 Guide
ICD-10 CodesF13.221

F13.221

Billable

Sedative, hypnotic or anxiolytic dependence with intoxication delirium

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/05/2025

Code Description

ICD-10 F13.221 is a billable code used to indicate a diagnosis of sedative, hypnotic or anxiolytic dependence with intoxication delirium.

Key Diagnostic Point:

F13.221 refers to a condition characterized by a dependence on sedative, hypnotic, or anxiolytic substances, accompanied by episodes of delirium due to intoxication. This condition is often seen in individuals who misuse medications such as benzodiazepines or barbiturates, leading to both physical and psychological dependence. Symptoms of intoxication delirium may include confusion, altered consciousness, agitation, and hallucinations. The dependence can result in significant impairment in social, occupational, or other important areas of functioning. Treatment typically involves a combination of detoxification, psychological support, and rehabilitation programs aimed at addressing both the substance use disorder and the underlying mental health issues. Clinicians must carefully monitor patients for withdrawal symptoms and potential complications during treatment, as abrupt cessation of these substances can lead to severe withdrawal symptoms, including seizures and delirium tremens.

Code Complexity Analysis

Complexity Rating: High

High Complexity

Complexity Factors

  • Differentiating between dependence and intoxication symptoms
  • Need for comprehensive documentation of substance use history
  • Potential for co-occurring mental health disorders
  • Variability in treatment protocols across settings

Audit Risk Factors

  • Inadequate documentation of substance use history
  • Failure to specify the type of sedative or hypnotic used
  • Lack of evidence for delirium diagnosis
  • Inconsistent treatment documentation

Specialty Focus

Medical Specialties

Psychiatry

Documentation Requirements

Detailed history of substance use, mental health evaluations, and treatment plans.

Common Clinical Scenarios

Patients presenting with acute delirium, history of substance misuse, and co-occurring mental health disorders.

Billing Considerations

Ensure thorough documentation of both psychiatric and substance use assessments.

Addiction Medicine

Documentation Requirements

Comprehensive assessment of substance use patterns, withdrawal symptoms, and treatment response.

Common Clinical Scenarios

Patients undergoing detoxification and rehabilitation for sedative dependence.

Billing Considerations

Focus on documenting the treatment plan and patient progress in recovery.

Coding Guidelines

Inclusion Criteria

Use F13.221 When
  • According to ICD
  • 10 guidelines, F13
  • 221 should be used when both dependence and intoxication delirium are present
  • Documentation must clearly indicate the patient's substance use history and current symptoms

Exclusion Criteria

Do NOT use F13.221 When
No specific exclusions found.

Related ICD-10 Codes

Related CPT Codes

H0031CPT Code

Mental health assessment

Clinical Scenario

Used during initial evaluation of a patient with suspected substance use disorder.

Documentation Requirements

Comprehensive assessment notes detailing substance use history and mental health status.

Specialty Considerations

Psychiatric evaluations should include specific inquiries about substance use.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of substance use disorders, improving the ability to track and manage these conditions. F13.221 provides a clear framework for identifying patients with complex needs related to sedative dependence and delirium.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of substance use disorders, improving the ability to track and manage these conditions. F13.221 provides a clear framework for identifying patients with complex needs related to sedative dependence and delirium.

Reimbursement & Billing Impact

The transition to ICD-10 has allowed for more specific coding of substance use disorders, improving the ability to track and manage these conditions. F13.221 provides a clear framework for identifying patients with complex needs related to sedative dependence and delirium.

Resources

Clinical References

  • •
    Substance Abuse and Mental Health Services Administration (SAMHSA)

Coding & Billing References

  • •
    Substance Abuse and Mental Health Services Administration (SAMHSA)

Frequently Asked Questions

What is the difference between F13.221 and F13.20?

F13.221 specifies that the patient has both dependence on sedatives, hypnotics, or anxiolytics and is experiencing intoxication delirium, while F13.20 indicates dependence without the acute delirium state.