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ICD-10 Guide
ICD-10 CodesK21.01

K21.01

Billable

Gastro-esophageal reflux disease with esophagitis, with bleeding

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/06/2025

Code Description

ICD-10 K21.01 is a billable code used to indicate a diagnosis of gastro-esophageal reflux disease with esophagitis, with bleeding.

Key Diagnostic Point:

Gastro-esophageal reflux disease (GERD) with esophagitis and bleeding is a condition characterized by the backward flow of stomach contents into the esophagus, leading to inflammation of the esophageal lining (esophagitis) and, in severe cases, bleeding. Clinically, patients may present with symptoms such as heartburn, regurgitation, chest pain, and difficulty swallowing. The anatomy involved includes the lower esophageal sphincter (LES), which normally prevents reflux, and the esophagus itself, which can become damaged due to the acidic content. Over time, chronic GERD can lead to complications such as Barrett's esophagus and esophageal strictures. Diagnostic considerations include endoscopy to visualize the esophagus and biopsy to assess for inflammation or dysplasia. The presence of bleeding indicates a more severe form of esophagitis, necessitating prompt medical evaluation and intervention to prevent further complications.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Diagnostic complexity: Requires endoscopic evaluation and possibly imaging studies.
  • Treatment complexity: May involve lifestyle modifications, medications, and potentially surgical interventions.
  • Documentation requirements: Detailed clinical documentation is necessary to support the diagnosis and severity.
  • Coding specificity: Requires accurate coding to differentiate from other forms of GERD and esophagitis.

Audit Risk Factors

  • Common coding errors: Misclassification of GERD severity or failure to document bleeding.
  • Documentation gaps: Incomplete clinical notes regarding symptoms or treatment plans.
  • Billing challenges: Potential denials due to lack of supporting documentation for the severity of the condition.

Specialty Focus

Medical Specialties

Gastroenterology

Documentation Requirements

Standard ICD-10-CM documentation requirements apply

Common Clinical Scenarios

Various clinical presentations within this specialty area

Billing Considerations

Follow specialty-specific billing guidelines

Internal Medicine

Documentation Requirements

Standard ICD-10-CM documentation requirements apply

Common Clinical Scenarios

Various clinical presentations within this specialty area

Billing Considerations

Follow specialty-specific billing guidelines

Related ICD-10 Codes

Related CPT Codes

CPT Code

Clinical Scenario

Documentation Requirements

CPT Code

Clinical Scenario

Documentation Requirements

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The clinical significance of K21.01 lies in its potential to lead to serious complications if left untreated, including esophageal ulcers and strictures. Population health impact is notable, as GERD is prevalent in a significant portion of the population, affecting quality of life and healthcare utilization. Quality measures may include monitoring the frequency of endoscopic evaluations and treatment adherence. Epidemiologically, the condition is associated with lifestyle factors such as obesity and diet, making it a target for preventive health strategies.

ICD-9 vs ICD-10

The clinical significance of K21.01 lies in its potential to lead to serious complications if left untreated, including esophageal ulcers and strictures. Population health impact is notable, as GERD is prevalent in a significant portion of the population, affecting quality of life and healthcare utilization. Quality measures may include monitoring the frequency of endoscopic evaluations and treatment adherence. Epidemiologically, the condition is associated with lifestyle factors such as obesity and diet, making it a target for preventive health strategies.

Reimbursement & Billing Impact

Reimbursement considerations include ensuring that the medical necessity for procedures such as endoscopy is clearly documented. Common denials may arise from insufficient documentation of the severity of the condition or failure to provide evidence of bleeding. Best practices include maintaining thorough clinical notes, ensuring all relevant symptoms and treatment plans are documented, and using appropriate modifiers when necessary to indicate the complexity of the case.

Resources

Clinical References

  • •
    ICD-10 Official Guidelines for K00-K99
  • •
    Clinical Documentation Requirements

Coding & Billing References

  • •
    ICD-10 Official Guidelines for K00-K99
  • •
    Clinical Documentation Requirements

Frequently Asked Questions

What specific conditions are covered by K21.01?

K21.01 covers gastro-esophageal reflux disease specifically with esophagitis and the presence of bleeding. This includes cases where the esophagus is inflamed due to chronic acid exposure, leading to ulceration and bleeding.

When should K21.01 be used instead of related codes?

K21.01 should be used when there is clear documentation of GERD accompanied by esophagitis and evidence of bleeding. If there is no esophagitis or bleeding, other codes such as K21.00 should be considered.

What documentation supports K21.01?

Documentation should include clinical notes detailing the patient's symptoms, results from endoscopic examinations, biopsy results, and any treatment plans that address the esophagitis and bleeding.