Secondary membranous nephropathy with nephrotic syndrome
ICD-10 N04.22 is a billable code used to indicate a diagnosis of secondary membranous nephropathy with nephrotic syndrome.
Secondary membranous nephropathy is characterized by the presence of immune complex deposition in the glomerular capillary walls, leading to increased permeability and resultant nephrotic syndrome. This condition often arises secondary to systemic diseases such as lupus erythematosus, infections, or malignancies. Clinically, patients present with significant proteinuria, often exceeding 3.5 grams per day, hypoalbuminemia, edema, and hyperlipidemia. Hematuria may also be present, although it is less common than in other forms of glomerulonephritis. Renal biopsy typically reveals subepithelial immune complex deposits and a thickening of the glomerular capillary walls. Management of secondary membranous nephropathy focuses on treating the underlying condition, controlling symptoms of nephrotic syndrome, and may include corticosteroids or immunosuppressive agents. Regular monitoring of renal function and proteinuria is essential to assess disease progression and response to therapy.
Detailed clinical history, laboratory results, renal biopsy findings, and treatment plans.
Patients presenting with nephrotic syndrome symptoms, renal function decline, or complications from nephrotic syndrome.
Ensure clear documentation of the nephrotic syndrome type and any underlying systemic diseases.
Comprehensive documentation of autoimmune conditions and their management.
Patients with lupus or other autoimmune diseases presenting with renal involvement.
Document the relationship between the autoimmune condition and the nephropathy.
Used when a renal biopsy is performed to confirm diagnosis.
Document indication for biopsy, findings, and any complications.
Nephrology specialists should ensure biopsy results are clearly linked to the diagnosis.
Primary membranous nephropathy occurs without an identifiable underlying condition, while secondary membranous nephropathy is associated with systemic diseases such as lupus, infections, or malignancies.
Nephrotic syndrome is diagnosed based on clinical symptoms such as edema, significant proteinuria (greater than 3.5 grams per day), hypoalbuminemia, and hyperlipidemia, often confirmed by renal biopsy.
