Nephropathy induced by other drugs, medicaments and biological substances
ICD-10 N14.1 is a billable code used to indicate a diagnosis of nephropathy induced by other drugs, medicaments and biological substances.
Nephropathy induced by other drugs, medicaments, and biological substances refers to kidney damage resulting from exposure to various pharmacological agents. This condition can manifest as acute interstitial nephritis, which is characterized by inflammation of the kidney interstitium, often triggered by medications such as non-steroidal anti-inflammatory drugs (NSAIDs), antibiotics, or diuretics. Pyelonephritis, an infection of the kidney, may also occur as a secondary complication due to urinary tract obstruction or reflux, often exacerbated by drug-induced changes in urinary flow or composition. Hydronephrosis, the swelling of a kidney due to a build-up of urine, can result from obstruction caused by drug-related effects. Drug-induced nephropathy is a significant concern in patients receiving multiple medications, particularly those with pre-existing renal impairment. Urinary tract infections (UTIs) may arise as a consequence of altered urinary tract dynamics, leading to further renal complications. Management typically involves discontinuation of the offending agent, supportive care, and, in some cases, antibiotic therapy to address secondary infections. Monitoring renal function is crucial in these patients to prevent progression to chronic kidney disease.
Comprehensive medication history, renal function tests, and clinical notes detailing the timeline of drug exposure and nephropathy onset.
Patients presenting with acute kidney injury following new medication initiation or dose adjustment.
Ensure clear documentation of the suspected drug and its relationship to renal impairment.
Detailed records of urinary tract infections, including culture results and antibiotic susceptibility.
Patients with recurrent UTIs and a history of nephrotoxic drug use.
Document the rationale for antibiotic choice and any adjustments based on renal function.
Used to evaluate renal function and detect urinary tract infections in patients with suspected drug-induced nephropathy.
Document the reason for urinalysis and any relevant findings.
Nephrologists should correlate urinalysis results with renal function tests.
Various medications can induce nephropathy, including NSAIDs, certain antibiotics (like penicillins and cephalosporins), diuretics, and chemotherapeutic agents. It's essential to review the patient's medication history to identify potential culprits.
