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ICD-10 Guide
ICD-10 CodesN46.025

N46.025

Billable

Azoospermia due to systemic disease

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/18/2025

Code Description

ICD-10 N46.025 is a billable code used to indicate a diagnosis of azoospermia due to systemic disease.

Key Diagnostic Point:

Azoospermia is defined as the absence of sperm in the ejaculate, which can be attributed to various underlying causes, including systemic diseases. Systemic diseases such as diabetes mellitus, cystic fibrosis, and certain autoimmune disorders can disrupt normal testicular function and spermatogenesis, leading to azoospermia. In these cases, the systemic condition affects the hormonal balance, blood flow, or the testicular environment necessary for sperm production. Conditions like hydrocele, orchitis, and other testicular disorders may also contribute to male infertility by causing inflammation or obstructing the reproductive tract. Orchitis, for instance, can lead to testicular damage and subsequent azoospermia. The management of azoospermia due to systemic disease often requires a multidisciplinary approach, including andrological evaluation, hormonal assessments, and possibly treatment of the underlying systemic condition. Male infertility specialists may also explore assisted reproductive technologies, such as sperm retrieval techniques, if sperm production is salvageable. Understanding the interplay between systemic diseases and male reproductive health is crucial for effective diagnosis and treatment.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Variety of systemic diseases that can lead to azoospermia
  • Need for comprehensive patient history and documentation
  • Potential overlap with other male infertility codes
  • Complexity in determining the primary cause of azoospermia

Audit Risk Factors

  • Inadequate documentation of the systemic disease
  • Failure to link azoospermia to the underlying condition
  • Misclassification of the type of azoospermia
  • Lack of supporting clinical evidence for the diagnosis

Specialty Focus

Medical Specialties

Urology

Documentation Requirements

Detailed patient history, including systemic disease diagnosis, treatment plans, and any relevant laboratory results.

Common Clinical Scenarios

Evaluation of male infertility, management of testicular disorders, and treatment of orchitis.

Billing Considerations

Ensure clear documentation of the relationship between systemic disease and azoospermia.

Endocrinology

Documentation Requirements

Hormonal assessment results, treatment plans for systemic diseases, and their impact on reproductive health.

Common Clinical Scenarios

Management of hormonal imbalances affecting fertility, such as hypogonadism due to systemic disease.

Billing Considerations

Document the endocrine evaluation and its correlation with azoospermia.

Coding Guidelines

Inclusion Criteria

Use N46.025 When
  • Follow the official ICD
  • CM coding guidelines, ensuring accurate documentation of the systemic disease leading to azoospermia
  • Include any relevant laboratory findings and treatment plans
  • Ensure that the code reflects the specific cause of azoospermia and is supported by clinical documentation

Exclusion Criteria

Do NOT use N46.025 When
No specific exclusions found.

Related ICD-10 Codes

Related CPT Codes

89320CPT Code

Semen analysis, including sperm count

Clinical Scenario

Used when evaluating male infertility and confirming azoospermia.

Documentation Requirements

Document the reason for the semen analysis and any relevant patient history.

Specialty Considerations

Urologists and fertility specialists should ensure comprehensive documentation of findings.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of azoospermia, enabling better tracking of causes and improving the understanding of male infertility. This specificity aids in research and treatment planning.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of azoospermia, enabling better tracking of causes and improving the understanding of male infertility. This specificity aids in research and treatment planning.

Reimbursement & Billing Impact

The transition to ICD-10 has allowed for more specific coding of azoospermia, enabling better tracking of causes and improving the understanding of male infertility. This specificity aids in research and treatment planning.

Resources

Clinical References

  • •
    ICD-10-CM Official Guidelines for Coding and Reporting

Coding & Billing References

  • •
    ICD-10-CM Official Guidelines for Coding and Reporting

Frequently Asked Questions

What is the primary cause of azoospermia in systemic diseases?

The primary cause is often hormonal imbalance or testicular dysfunction resulting from the systemic disease, which disrupts normal spermatogenesis.