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ICD-10 Guide
ICD-10 CodesO26.643

O26.643

Billable

Intrahepatic cholestasis of pregnancy, third trimester

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/08/2025

Code Description

ICD-10 O26.643 is a billable code used to indicate a diagnosis of intrahepatic cholestasis of pregnancy, third trimester.

Key Diagnostic Point:

Intrahepatic cholestasis of pregnancy (ICP) is a liver disorder that occurs during pregnancy, characterized by intense itching and elevated bile acids in the bloodstream. It typically manifests in the third trimester and can lead to complications for both the mother and fetus. The exact etiology is not fully understood, but it is believed to involve hormonal changes and genetic predisposition. Maternal symptoms include pruritus, particularly on the palms and soles, and potential jaundice. The condition is associated with an increased risk of preterm birth, fetal distress, and stillbirth. Management often includes monitoring bile acid levels, symptom relief, and in some cases, early delivery to mitigate risks to the fetus. Close collaboration between obstetricians and maternal-fetal medicine specialists is essential for optimal outcomes.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Requires understanding of liver function tests and their implications in pregnancy.
  • Differentiation from other pruritic conditions in pregnancy.
  • Need for monitoring and potential intervention strategies.
  • Documentation of maternal and fetal monitoring and outcomes.

Audit Risk Factors

  • Inadequate documentation of symptoms and laboratory results.
  • Failure to document the management plan and follow-up.
  • Misclassification of the condition with other liver disorders.
  • Lack of clear linkage between diagnosis and any procedures performed.

Specialty Focus

Medical Specialties

Obstetrics and Gynecology

Documentation Requirements

Detailed documentation of maternal symptoms, laboratory results, and management plans is essential. This includes bile acid levels, liver function tests, and any interventions performed.

Common Clinical Scenarios

Common scenarios include a pregnant patient presenting with itching and elevated bile acids, requiring monitoring and potential early delivery.

Billing Considerations

Consideration of the timing of delivery and monitoring of fetal well-being is crucial.

Maternal-Fetal Medicine

Documentation Requirements

High-risk pregnancy documentation needs to include comprehensive assessments of both maternal and fetal health, including ultrasound findings and fetal monitoring.

Common Clinical Scenarios

Complex scenarios may involve managing a patient with ICP who has a history of stillbirth or other complications.

Billing Considerations

Close monitoring of fetal heart rate and potential interventions to prevent adverse outcomes.

Coding Guidelines

Inclusion Criteria

Use O26.643 When
  • 10 coding guidelines for obstetric conditions emphasize the need for specificity in documentation, including the trimester of pregnancy and any associated complications
  • Accurate coding requires understanding the clinical implications of the diagnosis and its management

Exclusion Criteria

Do NOT use O26.643 When
No specific exclusions found.

Related ICD-10 Codes

Related CPT Codes

99214CPT Code

Established patient office visit, level 4

Clinical Scenario

Used for follow-up visits to monitor ICP and manage symptoms.

Documentation Requirements

Documentation must include assessment of symptoms, lab results, and management plan.

Specialty Considerations

Obstetricians should ensure comprehensive documentation to support the level of service billed.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of obstetric conditions like ICP, improving the ability to track outcomes and manage care effectively. The granularity of ICD-10 codes helps in understanding the complexities of pregnancy-related liver disorders.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of obstetric conditions like ICP, improving the ability to track outcomes and manage care effectively. The granularity of ICD-10 codes helps in understanding the complexities of pregnancy-related liver disorders.

Reimbursement & Billing Impact

The transition to ICD-10 has allowed for more specific coding of obstetric conditions like ICP, improving the ability to track outcomes and manage care effectively. The granularity of ICD-10 codes helps in understanding the complexities of pregnancy-related liver disorders.

Resources

Clinical References

  • •
    ACOG Practice Bulletin on Intrahepatic Cholestasis of Pregnancy

Coding & Billing References

  • •
    ACOG Practice Bulletin on Intrahepatic Cholestasis of Pregnancy

Frequently Asked Questions

What are the common symptoms of intrahepatic cholestasis of pregnancy?

Common symptoms include intense itching, particularly on the palms and soles, and in some cases, jaundice. These symptoms typically arise in the third trimester and can significantly impact the quality of life for the mother.