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ICD-10 Guide
ICD-10 CodesR65.10

R65.10

Systemic inflammatory response syndrome (SIRS) of non-infectious origin without acute organ dysfunction

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/11/2025

Code Description

ICD-10 R65.10 is a billable code used to indicate a diagnosis of systemic inflammatory response syndrome (sirs) of non-infectious origin without acute organ dysfunction.

Key Diagnostic Point:

Systemic Inflammatory Response Syndrome (SIRS) is a clinical syndrome characterized by a systemic inflammatory response to a variety of clinical insults, which may be infectious or non-infectious in origin. In the case of R65.10, the SIRS is of non-infectious origin and does not involve acute organ dysfunction. Symptoms typically include fever (temperature > 38°C or < 36°C), tachycardia (heart rate > 90 beats per minute), tachypnea (respiratory rate > 20 breaths per minute or arterial CO2 tension < 32 mmHg), and leukocytosis (white blood cell count > 12,000 cells/mm³) or leukopenia (white blood cell count < 4,000 cells/mm³). Common non-infectious causes include trauma, pancreatitis, burns, and autoimmune disorders. The absence of acute organ dysfunction is a critical aspect of this diagnosis, as it differentiates SIRS from sepsis, which involves organ failure. Accurate identification and documentation of the underlying cause are essential for appropriate coding and management.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Differentiating between infectious and non-infectious causes
  • Identifying the absence of acute organ dysfunction
  • Documenting specific symptoms and signs accurately
  • Understanding the clinical context of SIRS

Audit Risk Factors

  • Inadequate documentation of symptoms and signs
  • Failure to specify the non-infectious cause
  • Misinterpretation of organ dysfunction status
  • Inconsistent coding practices across providers

Specialty Focus

Medical Specialties

Internal Medicine

Documentation Requirements

Comprehensive documentation of clinical findings, including vital signs and laboratory results, is essential. The underlying cause of SIRS must be clearly stated.

Common Clinical Scenarios

Patients presenting with unexplained fever, tachycardia, and elevated white blood cell counts due to conditions like pancreatitis or autoimmune disorders.

Billing Considerations

Ensure that the absence of acute organ dysfunction is explicitly documented to support the use of R65.10.

Emergency Medicine

Documentation Requirements

Detailed acute care documentation is necessary, including initial assessment findings and any interventions performed.

Common Clinical Scenarios

Patients arriving with signs of SIRS following trauma or burns, requiring immediate evaluation and management.

Billing Considerations

In emergency settings, rapid assessment and documentation of vital signs and lab results are critical for accurate coding.

Coding Guidelines

Inclusion Criteria

Use R65.10 When
  • According to ICD
  • 10 guidelines, SIRS must be diagnosed based on specific clinical criteria, including at least two of the following: temperature abnormalities, tachycardia, tachypnea, and leukocyte count abnormalities
  • The absence of acute organ dysfunction must be documented

Exclusion Criteria

Do NOT use R65.10 When
No specific exclusions found.

Related CPT Codes

99285CPT Code

Emergency department visit, high severity

Clinical Scenario

Used for patients presenting with SIRS symptoms in the emergency department.

Documentation Requirements

Documentation must support the high severity of the visit, including vital signs and clinical findings.

Specialty Considerations

Emergency medicine providers should ensure thorough documentation of SIRS criteria.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has provided more specificity in coding SIRS, allowing for better differentiation between infectious and non-infectious origins. This specificity aids in appropriate treatment and resource allocation.

ICD-9 vs ICD-10

The transition to ICD-10 has provided more specificity in coding SIRS, allowing for better differentiation between infectious and non-infectious origins. This specificity aids in appropriate treatment and resource allocation.

Reimbursement & Billing Impact

reimbursement.

Resources

Clinical References

  • •
    ICD-10-CM Official Guidelines for Coding and Reporting

Coding & Billing References

  • •
    ICD-10-CM Official Guidelines for Coding and Reporting

Frequently Asked Questions

What are the key symptoms to document for R65.10?

Key symptoms include fever, tachycardia, tachypnea, and abnormal white blood cell counts. Documentation must confirm the absence of acute organ dysfunction.