ICD-10 Logo
ICDxICD-10 Medical Coding
ICD-10 Logo
ICDxICD-10 Medical Coding
ICD 10 CodesDiagnoses
ICD 10 CodesDiagnoses
ICD-10 Logo
ICDxICD-10 Medical Coding

Comprehensive ICD-10-CM code reference with AI-powered search capabilities.

© 2025 ICD Code Compass. All rights reserved.

Browse

  • All Chapters
  • All Categories
  • Diagnoses

Tools

  • AI Code Search
ICD-10-CM codes are maintained by the CDC and CMS. This tool is for reference purposes only.
v1.0.0
ICD-10 Guide
ICD-10 CodesR65.21

R65.21

Severe sepsis with septic shock

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/11/2025

Code Description

ICD-10 R65.21 is a billable code used to indicate a diagnosis of severe sepsis with septic shock.

Key Diagnostic Point:

Severe sepsis with septic shock is a critical condition characterized by a systemic inflammatory response to infection leading to organ dysfunction and hypotension. Symptoms may include fever, chills, rapid heart rate, confusion, and difficulty breathing. Clinically, patients may present with signs of organ failure, such as altered mental status, decreased urine output, and elevated lactate levels. Laboratory findings often reveal leukocytosis or leukopenia, thrombocytopenia, and elevated inflammatory markers like C-reactive protein (CRP) and procalcitonin. Septic shock is defined by persistent hypotension despite adequate fluid resuscitation, requiring vasopressor support. This condition demands immediate medical intervention and is associated with high morbidity and mortality rates, necessitating prompt recognition and treatment.

Code Complexity Analysis

Complexity Rating: High

High Complexity

Complexity Factors

  • Need for precise documentation of organ dysfunction
  • Differentiation between sepsis and severe sepsis
  • Recognition of septic shock criteria
  • Variability in clinical presentation

Audit Risk Factors

  • Inadequate documentation of organ dysfunction
  • Failure to document the presence of infection
  • Misclassification of sepsis severity
  • Lack of clarity in treatment protocols followed

Specialty Focus

Medical Specialties

Internal Medicine

Documentation Requirements

Detailed notes on patient history, physical examination findings, and lab results indicating organ dysfunction.

Common Clinical Scenarios

Patients presenting with fever, tachycardia, and altered mental status in the context of known infections.

Billing Considerations

Ensure all organ systems are evaluated and documented to support the diagnosis of severe sepsis.

Emergency Medicine

Documentation Requirements

Immediate assessment findings, including vital signs, lab results, and response to initial treatment.

Common Clinical Scenarios

Acute presentations of patients with suspected infections leading to shock.

Billing Considerations

Rapid documentation of interventions and patient response is crucial for accurate coding.

Coding Guidelines

Inclusion Criteria

Use R65.21 When
  • According to ICD
  • 10 guidelines, severe sepsis with septic shock must be documented with evidence of infection and organ dysfunction
  • Clinical criteria for septic shock must be met, including persistent hypotension despite fluid resuscitation

Exclusion Criteria

Do NOT use R65.21 When
No specific exclusions found.

Related CPT Codes

99285CPT Code

Emergency department visit, high severity

Clinical Scenario

Used when a patient with severe sepsis presents to the emergency department.

Documentation Requirements

Document the severity of the condition and the complexity of medical decision-making.

Specialty Considerations

Emergency medicine providers should ensure thorough documentation of the patient's condition and treatment.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of severe sepsis and septic shock, improving the accuracy of data collection and reimbursement processes.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of severe sepsis and septic shock, improving the accuracy of data collection and reimbursement processes.

Reimbursement & Billing Impact

reimbursement processes.

Resources

Clinical References

  • •
    Sepsis Clinical Guidelines

Coding & Billing References

  • •
    Sepsis Clinical Guidelines

Frequently Asked Questions

What is the difference between severe sepsis and septic shock?

Severe sepsis is characterized by organ dysfunction due to infection, while septic shock is defined by persistent hypotension despite adequate fluid resuscitation, indicating a more critical state.