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v1.0.0
ICD-10 Guide
ICD-10 CodesR74.8

R74.8

Abnormal levels of other serum enzymes

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/11/2025

Code Description

ICD-10 R74.8 is a billable code used to indicate a diagnosis of abnormal levels of other serum enzymes.

Key Diagnostic Point:

R74.8 refers to abnormal levels of serum enzymes that are not classified elsewhere. Serum enzymes are proteins that catalyze biochemical reactions and are often released into the bloodstream during tissue damage or disease processes. Abnormal levels can indicate a variety of conditions, including liver disease, myocardial infarction, muscle disorders, and metabolic syndromes. Commonly tested enzymes include alkaline phosphatase, lactate dehydrogenase, and creatine kinase. Clinicians may order these tests when patients present with symptoms such as jaundice, chest pain, or unexplained muscle weakness. The interpretation of enzyme levels must consider the patient's clinical context, including history, physical examination findings, and other laboratory results. Elevated enzyme levels may require further investigation to determine the underlying cause, which could range from benign conditions to serious diseases. Accurate coding of R74.8 is essential for proper diagnosis and treatment planning.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Variety of potential underlying conditions
  • Need for comprehensive clinical context
  • Differentiation from other enzyme-related codes
  • Potential for overlapping symptoms with other diagnoses

Audit Risk Factors

  • Inadequate documentation of clinical findings
  • Failure to specify the underlying cause of enzyme elevation
  • Misinterpretation of lab results
  • Inconsistent coding practices across providers

Specialty Focus

Medical Specialties

Internal Medicine

Documentation Requirements

Detailed patient history, physical examination findings, and rationale for enzyme testing.

Common Clinical Scenarios

Patients presenting with unexplained fatigue, jaundice, or abdominal pain.

Billing Considerations

Ensure correlation between enzyme levels and clinical symptoms to support diagnosis.

Emergency Medicine

Documentation Requirements

Acute care documentation including time of presentation, symptoms, and immediate lab results.

Common Clinical Scenarios

Patients with chest pain or acute abdominal pain requiring rapid assessment.

Billing Considerations

Document any immediate interventions and follow-up lab results to support coding.

Coding Guidelines

Inclusion Criteria

Use R74.8 When
  • Follow official ICD
  • CM guidelines for coding symptoms and abnormal findings
  • Ensure that the code is supported by clinical documentation and that the underlying cause is identified when possible

Exclusion Criteria

Do NOT use R74.8 When
No specific exclusions found.

Related CPT Codes

84450CPT Code

Liver enzyme panel

Clinical Scenario

Used when evaluating liver function in patients with jaundice.

Documentation Requirements

Document the reason for testing and any relevant clinical findings.

Specialty Considerations

Internal medicine specialists should correlate results with clinical symptoms.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of abnormal enzyme levels, improving the granularity of data for clinical analysis and reimbursement.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of abnormal enzyme levels, improving the granularity of data for clinical analysis and reimbursement.

Reimbursement & Billing Impact

reimbursement.

Resources

Clinical References

  • •
    ICD-10-CM Official Guidelines for Coding and Reporting

Coding & Billing References

  • •
    ICD-10-CM Official Guidelines for Coding and Reporting

Frequently Asked Questions

What should I document to support the use of R74.8?

Document the clinical context, including symptoms, lab results, and any follow-up evaluations that support the diagnosis of abnormal enzyme levels.