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v1.0.0
ICD-10 Guide
ICD-10 CodesR76.1

R76.1

Nonspecific reaction to test for tuberculosis

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/11/2025

Code Description

ICD-10 R76.1 is a billable code used to indicate a diagnosis of nonspecific reaction to test for tuberculosis.

Key Diagnostic Point:

R76.1 is used to classify a nonspecific reaction to a test for tuberculosis (TB), which may include a positive tuberculin skin test (TST) or interferon-gamma release assay (IGRA) without definitive evidence of active TB disease. This reaction indicates that the individual has been exposed to the TB bacteria, but it does not confirm active infection. The nonspecific nature of the reaction means that it could be due to prior vaccination (e.g., BCG vaccine), latent TB infection, or cross-reactivity with other mycobacterial infections. Clinicians must interpret these results in the context of the patient's clinical history, risk factors, and additional diagnostic tests to determine the appropriate management and follow-up. The presence of a nonspecific reaction necessitates further evaluation to rule out active TB disease and to assess the need for treatment or monitoring.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Interpretation of test results can vary based on patient history.
  • Differentiating between latent TB infection and active disease.
  • Potential for cross-reactivity with other mycobacterial infections.
  • Documentation of prior TB exposure or vaccination history is crucial.

Audit Risk Factors

  • Inadequate documentation of patient history related to TB exposure.
  • Failure to document the rationale for testing and subsequent findings.
  • Misclassification of latent TB infection as active TB.
  • Inconsistent coding of related conditions or tests.

Specialty Focus

Medical Specialties

Internal Medicine

Documentation Requirements

Detailed patient history, including risk factors for TB, vaccination status, and any symptoms suggestive of active TB.

Common Clinical Scenarios

Patients presenting with a positive TST or IGRA without active TB symptoms.

Billing Considerations

Consideration of the patient's immunocompromised status and potential for false-positive results.

Emergency Medicine

Documentation Requirements

Acute care notes should include the reason for TB testing, results, and any immediate management plans.

Common Clinical Scenarios

Patients with respiratory symptoms or recent exposure to TB who undergo testing in the emergency setting.

Billing Considerations

Rapid assessment of risk factors and potential need for isolation if active TB is suspected.

Coding Guidelines

Inclusion Criteria

Use R76.1 When
  • Follow the official ICD
  • CM coding guidelines, ensuring that R76
  • 1 is used only when there is a nonspecific reaction to TB testing without evidence of active disease
  • Document the clinical context and any follow
  • up actions taken

Exclusion Criteria

Do NOT use R76.1 When
No specific exclusions found.

Related CPT Codes

86580CPT Code

Tuberculin skin test

Clinical Scenario

Used for screening patients for TB exposure.

Documentation Requirements

Document the reason for the test, results, and any follow-up actions.

Specialty Considerations

Internal medicine and infectious disease specialists should ensure thorough documentation of patient history.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of nonspecific reactions, improving the granularity of data collection and analysis for TB testing outcomes.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of nonspecific reactions, improving the granularity of data collection and analysis for TB testing outcomes.

Reimbursement & Billing Impact

The transition to ICD-10 has allowed for more specific coding of nonspecific reactions, improving the granularity of data collection and analysis for TB testing outcomes.

Resources

Clinical References

  • •
    CDC Tuberculosis (TB) Fact Sheets

Coding & Billing References

  • •
    CDC Tuberculosis (TB) Fact Sheets

Frequently Asked Questions

When should R76.1 be used?

R76.1 should be used when a patient has a nonspecific reaction to a TB test without evidence of active TB disease. It is essential to document the clinical context and any follow-up evaluations.